ID A0A3B4H833_9CICH Unreviewed; 421 AA.
AC A0A3B4H833;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Pre-mRNA-splicing regulator WTAP {ECO:0000256|ARBA:ARBA00017540};
DE AltName: Full=Female-lethal(2)D homolog {ECO:0000256|ARBA:ARBA00033097};
DE AltName: Full=WT1-associated protein {ECO:0000256|ARBA:ARBA00032703};
DE AltName: Full=Wilms tumor 1-associating protein {ECO:0000256|ARBA:ARBA00032336};
GN Name=wtap {ECO:0000313|RefSeq:XP_005731064.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000029663.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000029663.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005731064.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the fl(2)d family.
CC {ECO:0000256|ARBA:ARBA00010313}.
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DR RefSeq; XP_005731064.1; XM_005731007.2.
DR AlphaFoldDB; A0A3B4H833; -.
DR STRING; 303518.ENSPNYP00000029663; -.
DR Ensembl; ENSPNYT00000030383.1; ENSPNYP00000029663.1; ENSPNYG00000022353.1.
DR GeneID; 102209454; -.
DR CTD; 9589; -.
DR GeneTree; ENSGT00390000013931; -.
DR OrthoDB; 2787589at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0080009; P:mRNA methylation; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR033757; WTAP.
DR PANTHER; PTHR15217:SF0; PRE-MRNA-SPLICING REGULATOR WTAP; 1.
DR PANTHER; PTHR15217; WILMS' TUMOR 1-ASSOCIATING PROTEIN; 1.
DR Pfam; PF17098; Wtap; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023}.
FT REGION 234..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..148
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 234..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 46172 MW; E35CB99D2AB19CFF CRC64;
MTNEEPLPKK VRLSESDMKT LTREELCARW KQHEAYVQVL EAKYAELCSN DVPGLKESEE
KLKQQQQESA RRENILVMRL ATKEQEMQEC TTQIQYLKQV QQPSVAQLRS SMVDPSINLF
FLKMKAELEQ TKDKLEQAQN ELSAWKFTPD SQTGKKLMAK CRMLIQENQE LGRQLSQGRI
AQLEAELALQ KKYSEELKSS QDELNDFIIQ LDEEVEGMQS TILVLQQQLK ETRQQLSQSQ
GSSAGAGPSR TSPTASSSCA EQSAQPEQAG APSETMGKDY GRVFNGPSNG SSSQRSETTT
PSLYREVSST EEDFPMSPMV SSPGEAETKL SNHSEEVTGS QTAAGRVGGP VGFGSQLSAG
YESVDSPTGS ETSLTQHSND TDSTTDPHED KAALVTKGSR TAGSRHAQNG LDTGTSDGAV
L
//
