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Database: UniProt
Entry: A0A3B4HBM4_9CICH
LinkDB: A0A3B4HBM4_9CICH
Original site: A0A3B4HBM4_9CICH 
ID   A0A3B4HBM4_9CICH        Unreviewed;      1586 AA.
AC   A0A3B4HBM4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN   Name=MADD {ECO:0000313|Ensembl:ENSPNYP00000032089.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000032089.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000032089.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the MADD family.
CC       {ECO:0000256|ARBA:ARBA00005978}.
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DR   Ensembl; ENSPNYT00000032859.1; ENSPNYP00000032089.1; ENSPNYG00000024217.1.
DR   GeneTree; ENSGT00940000156718; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR039980; MADD.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475}.
FT   DOMAIN          12..597
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          104..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          711..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          802..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          911..956
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1068..1099
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1137..1259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        732..749
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        828..845
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..876
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        935..956
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1160..1216
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1231..1257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1586 AA;  175780 MW;  F283F1C9CA60C2AD CRC64;
     MEKKKMCPRL LDYLVVVGAR QPTSDSVAQT PQLLRRYPLE DHQDFPLPPD VVFFCQPEGC
     LSIRQRRVSL RDDSSFVFTL TDKDSGITRY GICVNFYRSF QRGHHRTRGE KSSHAETAER
     ATETTSEGSD SGGGGVPHSV VSPPKNAESV PPPASGEEGG QQGAEQNAGK SPQHKRSAAK
     VAARNRNSTL TSLCILSHYP FFSTFRECLY ILKRLVDCCS QRLTQRAGLP RATQRDTMWR
     VFTGALSVEE KGSQLLADLR EIESWVYRLL RSPVPVAGQR RVDVEVLPHE LKRPLTFALP
     DSSRFSMVDF PLHLPLELLG VDACLQVLSC VLLEHKVILQ SRDYNALSMS VMAFVAMIYP
     LEYMFPVIPL LPTCMASAEQ LLLAPTPYII GVPASFFLYK SDFKMPDDIW LVDLDSSKVI
     APTNAELLPP LPEPEAGELK KHLKQCLVRL TVITQKQIFS SENKALTSMS LNTQPILNLE
     KFQEGQEMPL LPPGRDKASP SSTEFNPLIY GNDVDSVDVA TRVAMVRFFN SPNVLQGFQM
     HTRTLRLFPR PVVAFQSTSF LASRPRRSTF ADKLSHTQAV EFYGEWALNP TNLAFQRIHN
     NVFDPSLIGD KPKWYAHQLQ PVVYRVYDGS SQLVEAMAGP LEDEGNESDP TDSGSDSEAY
     DDSSSSYSSL GDLVSEMIQG DIQGDTPSLD PPTHAALGDA SEVEFQDYHD FREGHGSEGP
     PSGDGPAEPS DGQPLRSSSS TTASSSPSTI IQGVNHEQGE VPEIEASASA ALQNPVPGLA
     NQPFLRPAAD AGLVEQANKK QEYDNPYFEP QYGFPSEDDP DAEEQVESYT PRFNQNLNGN
     KAQRPLRPSS LRLPGESDGE GDSRNSSPNS TISNNSNDGF GGLMSFASNL YKNHGTSFSL
     SNLALPNKAA REKSTPFPSL KGARAPRALV DQKSSVIKHS PTVKRESPSP QGRVNNTSEN
     QQFLKEVVQS VLDGQGVGWL NMKKVRRLLE NEQLRVFVLS KLNRAVQSEE DARQEIIRDV
     EVNRKVYKGM LDILKCTVSS LEHSYTNAGL GGMASVFSLL EIARTHYQTK DPEKRKRSPT
     DSAGSPGSKE SPSGRMETAR PQGLLNIPHL QLPHHTTGKG ARHFDTRSLN EENFIASIGS
     EGAKQQRPQV TDAEEKKSQI SADSGLSVTS GSQKSDTESV ASSEPPILTR STSQDSEAST
     VISNSSGETL GADSDLSSTA GDGLGGRTAP HLTQSRGTLS DSEIETNPAT SSVFGKTHTL
     KPGVKDHLPA LAKGLPAQPI EDTSMRIYLF EGLLGRDKSS VWDQLEDAAM ETFSLSKERS
     TLWDQVQFWE DAFLDAVMLE REGMGMDQGP QEMIERYLSL GEHDRKRLED DEDRLLATLL
     HNMIAYMLMM KVSKNDIRKK VRRLMGKSHI GLTYSQEINE ILDKLAQMNG RELSIRPSGS
     RHIKKQTFVV HAGTDTTGDI FFMEVCDDCI VLRSNIGTVY ERWWYEKLIN MTYCPKTKVL
     CLWRRNGQET QLNKFYTKKC RELYYCVKDS MERAAARQQS IKPGPELGGE FPVQDMKTGE
     GGLLQVTLEG INLKFMHSQF LKLKKW
//
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