ID A0A3B4HBS4_9CICH Unreviewed; 109 AA.
AC A0A3B4HBS4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Pyruvate dehydrogenase E1 alpha 1 subunit {ECO:0000313|Ensembl:ENSPNYP00000032154.1};
DE SubName: Full=Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial {ECO:0000313|RefSeq:XP_005752510.1};
GN Name=pdha1 {ECO:0000313|RefSeq:XP_005752510.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000032154.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000032154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005752510.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR RefSeq; XP_005752510.1; XM_005752453.2.
DR AlphaFoldDB; A0A3B4HBS4; -.
DR STRING; 303518.ENSPNYP00000032154; -.
DR Ensembl; ENSPNYT00000032925.1; ENSPNYP00000032154.1; ENSPNYG00000024273.1.
DR GeneID; 102193164; -.
DR CTD; 436672; -.
DR GeneTree; ENSGT00530000063174; -.
DR OrthoDB; 166915at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|RefSeq:XP_005752510.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 1..80
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 109 AA; 12652 MW; 69AA8AFC6CEEA364 CRC64;
MELQTYRYHG HSMSDPGVSY RTREEIQEVR SKSDPISMLK ERMLSHNMAS VEEFKEIDIE
IRKQVEDATQ FATSDPEPPL EELCNHIFSN NPLLEVRGTN PWSKLKSVS
//
