ID A0A3B4HDE9_9CICH Unreviewed; 737 AA.
AC A0A3B4HDE9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Mitofusin 2 {ECO:0000313|Ensembl:ENSPNYP00000031971.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000031971.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000031971.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
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DR AlphaFoldDB; A0A3B4HDE9; -.
DR Ensembl; ENSPNYT00000032736.1; ENSPNYP00000031971.1; ENSPNYG00000024126.1.
DR GeneTree; ENSGT00390000013727; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR CDD; cd09912; DLP_2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR006884; Fzo/mitofusin_HR2.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027094; Mitofusin_fam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10465:SF1; MITOFUSIN-2; 1.
DR PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF04799; Fzo_mitofusin; 1.
DR SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 631..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..343
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
SQ SEQUENCE 737 AA; 83289 MW; 3E9C2068CBA79059 CRC64;
MSLVFPRLST NPFHSKKEKR IMAEVNASPL KHFVTAKKKI NGIFEQLGAY IKESASFLEE
AYKSEELDPV ATEEQVQEVQ GYLAKVTGIG EVLARRHMKV VFFGRTSNGK SSVINAMLCD
KVLPSGIGHT TNCFLRVEGT DGNEAFILTG GSEERKNIKT VNQLAHALHQ DEDLDAGSLV
CVMWPKAKCA LLRDDLVLVD SPGIDVTTEL DSWIDKFCLD ADVFVLVANS ESTLMQTEKS
FFHKVNERLS SPNIFILNNR WDASASEPEY MEEVRGQHMD RCTNFLVDEL GVVDRAQAGD
RIFFVSAKEV LQARVQKAQG MPEAGGALAE GFQARMFEFQ NFERRFEECI SQSAVKTKFE
QHTVRAKQIS EALRHIMDSV YIAAQEQRVY CLETKEDRQD RLEFIDKQLD LLTMDCKSKI
KKITEEVERQ VSNAMAEEIR KLHVLVDDFH MVFHPSPVVL KVYKNELHRH IEEGLGKNMS
ERCSTSISSA LQTTQNDMIE GLKPLLPSAV REQVDKLVPR SQCFSLSYDL ACDKLCSDFQ
EDISFHFSLG WTMLVNRFLG PKNTRRVLMG YNDQVPRPMA LTPVSTSMPP FPQSAMTQEE
LMVSMVTGLA SLTSRTSMGV LVIGGVIWKA VGWRLIALSL GLYGLLYIYE RLTWTTKAKE
RAFKRQFVDY ASEKLQLIVS YTGSNCSHQV QQELAGVFAQ LCQQVDITRQ NLEDDITDMN
SKIELLDSLQ SKAKLLR
//
