ID   A0A3B4T310_SERDU        Unreviewed;       514 AA.
AC   A0A3B4T310;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Ras protein-specific guanine nucleotide-releasing factor 2a {ECO:0000313|Ensembl:ENSSDUP00000000543.1};
GN   Name=RASGRF2 {ECO:0000313|Ensembl:ENSSDUP00000000543.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000000543.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000000543.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4T310; -.
DR   STRING; 41447.ENSSDUP00000000543; -.
DR   Ensembl; ENSSDUT00000000584.1; ENSSDUP00000000543.1; ENSSDUG00000000440.1.
DR   GeneTree; ENSGT00940000155679; -.
DR   OMA; NTERECK; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          22..130
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          240..426
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          458..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          148..185
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        461..476
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   514 AA;  59550 MW;  8547BB0362B27D91 CRC64;
     MQKSVRYNEG HALYLSVVAR KEGTKRGFLS KKTTENSRWT EKYFALYQNV LFYFENDQST
     RPSGIYLLEG CTCERAPAPK VSVLGPAGLF MSKHYFLVIF GHEGQKPLEL RTEEESDCNE
     WVECITQASY SDIIIEREIL MQKYIHLVQI METEKIAANQ LRTQLEDQDT EIERLKAEIV
     VLNKAKERMQ PHQNNQEEED PDIKKIKKVQ SFMRGWLCRR KWKIIVQDYI CSPHAESMRK
     RNQIVFNMVE AETEYVHQLS ILVNCFLRPL RMAASSKKPP ISHDDVSSIF LNSETIMFLH
     EIFHQGLKAR IANWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQVLANC KQNRDFDKLL
     KQYESNAACE GRMLETFLTY PMFQIPRYII TLHELLAHTP HEHVERKSLE FAKSKLEELS
     KMMHDEVSDT ENIRKNLAIE RMIVEGCDIL LDTSQTFVRQ GETPPPPPPP PPPQHITLSQ
     TSITSLSLPL SLYLSAGARL SHPAAVQQRA GRAQ
//