ID A0A3B4T476_SERDU Unreviewed; 1077 AA.
AC A0A3B4T476;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Retinoblastoma-like protein 2 {ECO:0000313|Ensembl:ENSSDUP00000000948.1};
GN Name=RBL2 {ECO:0000313|Ensembl:ENSSDUP00000000948.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000000948.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000000948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; A0A3B4T476; -.
DR STRING; 41447.ENSSDUP00000000948; -.
DR Ensembl; ENSSDUT00000000992.1; ENSSDUP00000000948.1; ENSSDUG00000000771.1.
DR GeneTree; ENSGT00950000183202; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20606; CYCLIN_RBL2; 1.
DR CDD; cd00043; CYCLIN_SF; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 63..205
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 377..570
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 783..946
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 959..1077
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 589..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 119867 MW; FA74F2723DA888B0 CRC64;
MSDEDEFLQK ARAGFEDLCR ALNMDEEAST EAWKTYENIS RNFTLEGSEL HWLACALYVA
CRSSVPTVGK GTVEGNYVSL TRILRCSEMS LIEFFNKMKK WQDMADLPQD FRQSTEKLER
NFTVSAVIFK KYVPIFKAIF KAPSEEPPRV HRSRKQRRHP CTVTEVFNFC WVLFVHAKGN
FPMISDDLVN SYHLLLCALD LVFTNALLCH ARKDLLNPDF TGLPEDFSSK DYRPSSGPYC
FIEQLCELHE GLVLEAKGVK EHFWKPFIKK LFHKRILRGK EDSLTGFLDP MNFGDSFLSL
SRVYEEHVLA TGSLDERIFT GEGASEDIGT PGPCLCEGVE NQDSATYRLH TNLTASALKV
STPLTGRKYV QENSLASPVS SAMKSVGRLH TLLSGTKQGP SPKLTETLRT CARDPSDVIS
KRLKDMFDLF SQHYEKSGAE KRGMGKDMAV KYFHLAEALY YRILESIIER EKMILGDADL
SCILEQDIFH RSLLACCLEI VTFSYRPPGD FPNVITIFQL PAYHFYKVIE VLVRSEQGLF
REVVKHLNQV EEQVLESLAW TRDSPLWESL RGAKDLVPAC QEVMPPQYLE QNDDSSTGSV
PNTPVNHGPE LNTNSTVKGV SPSPTTLLDR YSSSPTGTAR RRLFVDPVDG ETGVTSTSST
STTSTTPTSV TKTRQASLVT AIPAGQTVVT MATATVTANN GQTVTIPVQG IANESGGITF
IPVQVSVTGQ GGATLQPLSA QTLTGTLTVQ SAVTKPAAKP ASSPLRKGSL SLFFRKVYHL
ASVRLRDLCA KLDISSELRR KIWTCFEYSL VHCTDLMMDR HLDQLLMCAV YVMAKVTKED
KSFQNIMKCY RTQPQASSNV YRSVLISGRR RRHSGTNDTN KQNSSPDTSL DPAGGDNSPV
PIRSSSTLPA PQPGSAPSTP NKNPSSSSSA EEERGDLIHF YNNVYIKQMR LFALRYSPSS
PSAGVESPSL CPYPTLRIGS PRRMLLSSKH SIYISPHKTG SAPSPTTPRD KIYYYICSSP
PNRLQEINSM IRTGETPTRK RSMPLEDETS PKRVCPDNHS ALLRRLQDVA NDRSSSH
//
