ID   A0A3B4T6W7_SERDU        Unreviewed;       436 AA.
AC   A0A3B4T6W7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Homeobox-containing protein 1-like {ECO:0000313|Ensembl:ENSSDUP00000001883.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000001883.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000001883.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR   AlphaFoldDB; A0A3B4T6W7; -.
DR   Ensembl; ENSSDUT00000001945.1; ENSSDUP00000001883.1; ENSSDUG00000001456.1.
DR   GeneTree; ENSGT00940000154928; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR040363; HMBOX1.
DR   InterPro; IPR006899; HNF-1_N.
DR   InterPro; IPR044869; HNF-1_POU.
DR   InterPro; IPR044866; HNF_P1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   PANTHER; PTHR14618; HOMEODOX-CONTAINING PROTEIN 1 HMBOX1; 1.
DR   PANTHER; PTHR14618:SF5; ZGC:91944; 1.
DR   Pfam; PF04814; HNF-1_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS51937; HNF_P1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS51936; POU_4; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          36..67
FT                   /note="HNF-p1"
FT                   /evidence="ECO:0000259|PROSITE:PS51937"
FT   DOMAIN          149..245
FT                   /note="POU-specific atypical"
FT                   /evidence="ECO:0000259|PROSITE:PS51936"
FT   DOMAIN          270..345
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        272..346
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..436
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  49115 MW;  9CBE70ED0AE86330 CRC64;
     MRQWCVPAAT PRTEPLPGRL SVSPPPSDAR MECCEVEPRY TIEQIDLLQR LRLSGMTKPQ
     IIHALESLER LDPDHRPSHC DSHPAPSNNT PTTAAPAPSS SSSSSSSSLS LASATTQTSG
     LDGAALSPSH SYEASPPPLF PPSVAVQRSF SYDMMGEEEW DLEEKVEEYM RRDSNLVKEE
     IKTFLNNRRI SQAIVGQVTG ISQSYISQWL LQQGLEMSDS KRRAFYRWYL LERNNPGATL
     SMRSLVKEEP DWRTGIMSGD RAGMVSGPLR LRRGSRFTWR KECQSIMESF FMENQYPDEA
     KREEIASACN SVIQKPGCKL SEFERVTALK VYNWFANRRK EMKRRANIEA AILESHGIEV
     PSPSCHSNGE EGEMHEFADQ VTHRFSEQED TSSQRIVDQQ DPSSLATTEV AALPSPTPQV
     LEQKEEDSKR ETVDEE
//