ID A0A3B4T7I4_SERDU Unreviewed; 1951 AA.
AC A0A3B4T7I4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000001917.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000001917.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 41447.ENSSDUP00000001917; -.
DR Ensembl; ENSSDUT00000001978.1; ENSSDUP00000001917.1; ENSSDUG00000001440.1.
DR GeneTree; ENSGT00940000154992; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF292; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 228..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 251..274
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 391..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 721..739
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 751..774
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 831..859
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 919..944
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1145..1164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1185..1201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1213..1232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1277..1297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1384..1407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1466..1484
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1496..1518
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1530..1549
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1597..1619
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1687..1710
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 128..424
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 526..614
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 720..951
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 958..1140
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1144..1416
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1465..1720
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 31..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1072
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1951 AA; 221731 MW; 03896091B3B8E18F CRC64;
MAAMLLPTGP DGLRRFTRES LAAMEQRIAE EQAKNAKGCQ EAHRNAEPPK PRADLEAGKQ
LPRIFGDIPT ELIGVPLEDI DPFYYKNQRT FIVLNKGKAI FRFSATSALY IFSPFHFIRT
IAIKVLVHSL FSLFIMFTIL TNCFFMAMSD PAPWTKYLEY TFTAIYTFES AIKILARGFC
LLPFTFLRDP WNWLDFSVIV MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
LIQSVKKLAD VMILTVFCLS VFALIGLQLF MGLLRQKCVR SLTHCINSSY SPNASFICNN
RTWSSRADFL SSEDNFYKVE GAKDALICGY GNDAGKCPDG FDCLKVGRNP NYGYTSFDTF
GWAFLALFRL MTQDYWEKLF HQTLRSAGKT YMVFFVLVIF LGSFYLVNLI LAVVAMAYEE
QNQATIAEAW QKEREFQLAM EHLRREQRLA AKRQAQETDS VLSPELSPIC QKTGSIRRSS
CRRRRSHRTL SEETEEEAAE EKFDPLEEPM PPLSPLPVHP LLATLSSHPL STRRGSQVSI
FSSFRARNNS EADFGDDEYS IHGDAFRSRA SSTATPWKRR TGSVRSHCSQ VFTPSLTVNG
RLNISLDQNG VTAVGLHTPT SMLAYSMERV REDMKPAGAE DPVPRSLLQP SPTVTEPPPV
HRKRGLSSVS FLSDAMEELE ESRQKCHPCW YTFAKKYLIW DCCPWWLKMK EWVKCMVMDP
FLDLGITICI VLNTLFMALE HYPMTDEFNT MLSVGNLVFT GIFTAEMVLK LIAMDPYYYF
QQGWNIFDGV IVCLSLMELG LSNVEGLSVL RSFRLLRVFK LAKSWPTLNT LIKIIGNSVG
ALGNLTLVLA IIVFIFAVVG MQLFGKNYQD CVCKISNDCQ LPRWHMKDFF HSFLIVFRVL
CGEWIETMWD CMEVAGQPLC ILVFMLVMVI GNLVVLNLFL ALLLSSFSSD NLSAPDEDGD
LNNIQIAIAR INSGGSWLAT HVSDFYNHSV KRRKQKAKEA SQAIKLVSNH VESNGGVFGC
YGEKYVIPEE DSYMTNPNLT VIVPIAPGES DVEFLEEEEI SESSEDEDNK PEEVSLSEGS
TVDLRRPGDE IDDLSELAEE SMEPDECFPD LCMRYCQCCD IDTSRGLGQA WWRLRKTCYQ
IVEHSWFETF IIFMILLSSG ALAFEDIYIE KRKVVKVVLE YADKVFSYIF VLEMFLKWIA
YGFKKYFTNY WCWLDFLIVD VSLISLVANS LGYSDFAAIK SLRTLRALRP LRALSRFEGM
RVVVNALIGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GKCVNRTGFI HSVTVVNNKS
DCLGMNDTQF YWTKVKVNFD NVGLGYLSLL QVATFKGWME IMHAAVDSRG VEEQPIREIN
LYMYLYFVVF IIFGSFFTLN LFIGVIIDNF NQQKRKLGGQ DIFMTEEQKK YYNAMKKLGS
KKPQKPIPRP ANVLQAFFFD LVSKQAFDIM IMMLIIVNMV TMMVETDEQS ERMESVLNKI
NMVFIVVFTT ECLIKLFALR CYFFTVAWNI FDFVVIILSI VGIVLADIIE KYFVSPTLFR
VIRLARIGRV LRLIRAAKGI RTLLFALMMS MPALFNIGLL LFLVMFIYAI FGMANFAYVK
KQDGIDDMFN FETFGNSIIC LFQISTSAGW DNLLSPIMSS SPDECDAHFV NTGTNTRGNC
GSPSVGIAFF VSYIIISFLI VVNMYIAIIL ENFSVATEES TEPLSEDDFE MFYEVWEKFD
SEATQFIEFS MLSSFADTLS EPLRIAKPNM INLIAMDLPM VSGDRIHCLD ILFAFTKRVL
GESGDMDALK QQMEEKFMMT NPSKVSHEPI TSTLRRKLEE VSAIIIQRCY RRHLVRRQMK
QASYLYRQIN YETVVDVENA PETEGLIASM IQHYGPAGVE VVQTTEDTLM SSPPSYDSVT
RAVGDLSEVV RSISRDSELG EPGENYEETF L
//
