ID A0A3B4TA89_SERDU Unreviewed; 1680 AA.
AC A0A3B4TA89;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Complement C4-like {ECO:0000313|Ensembl:ENSSDUP00000003023.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000003023.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000003023.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR STRING; 41447.ENSSDUP00000003023; -.
DR Ensembl; ENSSDUT00000003097.1; ENSSDUP00000003023.1; ENSSDUG00000002239.1.
DR GeneTree; ENSGT00940000155739; -.
DR OMA; RVHYGFQ; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF144; COMPLEMENT C4-B; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1680
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017252181"
FT DOMAIN 652..690
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1524..1678
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1680 AA; 187825 MW; B0864F1B6A0F7862 CRC64;
MERHMISILL LIMTVDSVCS RFFISAPNVF HVGVTEKVLV QMGKPHLNRP VTLYLEFESS
GYVVSTKETV VCTNEQDIKT VELKINREMM SRLDSGKQKK PYLLLVAESP SFSSRKITRV
LVSKHRGYIF IQTNQPMYNP TQKVKYRIFT LDHTFRPHEE VFQISVINAA GNRVMKSLKT
AKGGILRGIF PIPDVSKMGT WKITAHYEGD EDNAVSREFK VQKFVLPSFE VNIAMEENYI
LLNAEQFNFT ISAMYSHGEK VKGAYHCQLG IVGKATTNGG KIKPITGLEL TGSVQDGTAE
VSLRTAKINN QLQNKMNQTL SDLQQSGAQL YLRLFVTNIQ SGEMQEAEVY LPVVSHKYTM
DLSRTRSYFL PGYPLDVVVV MSRPDGSAAA GVPVNINVPG SSEQSFQGIT DQEGAVFSTF
NIDTIDEIPV EVTTDGLQQR KVIRRASSPS NSYLYMSFSN KMHSVNHLLA VTYNTVNSPN
DGYIYYTVLS RGIIIKNGSH SIGRSVKHNL HITPDMVPSF RLIGYFYNQN GDIIADSVWV
DVTDECEIKV KVEHKGSVEP GRQSKLEFDL DGQSAKVALL AVDKAFYALN ADNKLTARKV
FSAMQSYDLG CSYGGGPDPV SVLRDAGLSF VSQSESGSKG ESNFSDEILQ ECCGHGLTLI
PMTLTCQERA KRVSLVRQNQ DCADAFLKCC LEGERLRQKK LQEDSLKGLG RTVTAADIEQ
FFLDTAAQYI RRLFPPSFAF TEFDVNGKRS YPLTLPDSIT TWEIQIITLS AASGFCVVKP
TEIRAFKNTF VSLRLPYSVR KYEQISISPV IYNYGSDQLK LAVHMEQTEG LCSPGSATTT
GFVNITVEPD SSQFVSFSAV PMVTGSIPIK IRVYDIENGN GIDAVEKTLN VWTEGLEQRV
EETKLIKLDG KRTLTLTLDG SLPDETVPDS SSNLFVSVEE NGFGSQVINL LSPEKVASLI
RLPTGCCEQT MSGLAPTAAA LRYLDLSEQW FTLPVGSRDD AFDKIEQGYV RVLTYKTSDG
SYKPWSSNAS GNWLSAFVLK VLSLVAQRQT VAFGQQGRKA RVVPVEDIRH TVRYLLSVQN
TDGSFSDPHP VLHRSVLKGK DREASLTAFV ALALHQSLQF LTSEARNDEE SISSSTMYLK
SNLAELQHPY AVAITAYCLS VCLPEGTDLS AVWTRLQAMA IERADGCYLW TTDPTTRNEK
KANAITVETT AYALLTAVAL KHTEWADKAA CWLISQENYF GTYRSTQDTV MALEALAEYD
LKRSNSPAAN LIAEFRVPGK NDIVTIALEN KEKVETDLKK LSGNNIAVQL SGKGQAKLKI
LKAYHLLEPK DDCLKLSISV TVEGKVKYTA KVIETYDYYE DYDTNEEKEG RVPRSAIEWF
DARTRSRRDV ENNLNSDETV TYRVCVSHSL SHNLSGMAIA DITLLSGFEA VTEDLDRLKQ
QPEQYISHYE VSYGRVLIYF NELLEPEECI SFDAIQRVPI GLLQPAPAVF YDYYEPDQKC
TVFYSAPQRS KMVSKLCSED VCQCAERPCH KLKMTFKLER NQYLKKNDRV QHACFFPTVD
YAYIVEVVSV SVKSNFELYN TTVTEVLRSH GDILVNENSV RVFVKRRQCK EQLHLGKQYL
LMGKDGSTTD SNGVMQYLLE SNTWVEKKPS DEQCKKSAHQ AACTGFSAFI NEYKMNGCRH
//
