ID   A0A3B4TEM1_SERDU        Unreviewed;       675 AA.
AC   A0A3B4TEM1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Histidine decarboxylase {ECO:0000256|ARBA:ARBA00039946};
DE            EC=4.1.1.22 {ECO:0000256|ARBA:ARBA00012320};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000004470.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000004470.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|ARBA:ARBA00009533}.
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DR   AlphaFoldDB; A0A3B4TEM1; -.
DR   STRING; 41447.ENSSDUP00000004470; -.
DR   Ensembl; ENSSDUT00000004564.1; ENSSDUP00000004470.1; ENSSDUG00000003241.1.
DR   GeneTree; ENSGT00940000157938; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0042423; P:catecholamine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 1.20.1340.10; dopa decarboxylase, N-terminal domain; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010977; Aromatic_deC.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   PANTHER; PTHR11999; GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR11999:SF68; HISTIDINE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   PRINTS; PR00800; YHDCRBOXLASE.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   3: Inferred from homology;
KW   Catecholamine biosynthesis {ECO:0000256|ARBA:ARBA00022584};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50}.
FT   REGION          478..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        502..517
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         306
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   675 AA;  75704 MW;  AA2FCD8D50E9C51D CRC64;
     KMQAEEYNRR GKELVDYITQ YLGSIRERRV IPDVKPGYMK ELLPDTAPTE PEDWETIFND
     IEKVVMPGVV HWQSPHMHAY YPSLTSWPSM LGDMLADAIN CVGFTWASSP ACTELEMNVM
     DWLCKALGLP SFFLHQHPDS RGGGILQSTV SESTLVALLA ARKDKILQLR AELDQEVDDS
     VLNSRLVAYA SDQAHSSVEK AGLISLVKIR FLPTDEQLSL RGDTLKQAIQ EDRRMGLVPF
     MLCATLGTTG VCAFDKLSEL GPVCAEEGLW LHVDAAYAGS AYFCPELRWS LEGIDFAHSF
     VFNPSKWMMV HFDCTAFWVK DKYKLQQTFS VDPVYLRHEN SQAATDFMHW QIPLSRRFRS
     LKLWFVMRSF GLKNLQAHIR HGIEMAKLLE SHIRRDPNFE VPAARHLGLV VFCLKGGNAL
     TQELLRRLTR SGTMYLIPAD IHTTRIIRFT VTSQFTTADD ILKDWGIISK TASTLLAETQ
     GPNNSDQSKA GEDDVMEAEE NQDPNSDTRS DEKEDAASML DKAQVELWID KAWNRSRRPM
     RSLSCNSEPL PYTYVGPLSG YDFDTRPALK DGAGALPTPS TPASSPLTKV TEMPSNLLGK
     QVLKKLTKFY SVPSFCNQWV QCGRHPLCCP LKVSQAAQKH LSSTCRRMNC MSSSPIANTA
     PSPTPLETAT APKLL
//