ID A0A3B4TFH4_SERDU Unreviewed; 1998 AA.
AC A0A3B4TFH4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Marker of proliferation Ki-67 {ECO:0000313|Ensembl:ENSSDUP00000004823.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000004823.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000004823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 41447.ENSSDUP00000004823; -.
DR Ensembl; ENSSDUT00000004923.1; ENSSDUP00000004823.1; ENSSDUG00000003593.1.
DR GeneTree; ENSGT00940000154352; -.
DR OMA; KPEQQEC; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR CDD; cd22673; FHA_Ki67; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR012568; KI67R.
DR InterPro; IPR029334; PP1-bd.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR21603; ANTIGEN KI-67-LIKE PROTEIN; 1.
DR PANTHER; PTHR21603:SF18; ANTIGEN KI-67-LIKE PROTEIN; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF15276; PP1_bind; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM01295; K167R; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 26..76
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 156..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1916..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1625..1641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1644..1661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1670..1699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1754..1797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1868..1884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1885..1901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1919..1968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1976..1991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1998 AA; 217917 MW; F934F3942F22C150 CRC64;
MPLHGKVVVI KRSGGDGTEF PLTATCLFGR KPDCDIRIQL PQVSKEHCRI DLNENKEVIL
TNLSSVNPTR VNGEALQQSE RLKHGDVITI IDRSFRFEYP PAPTPKKRSS AGGKSETLKV
LQAQQVVDIV TAETGEKRNS EVFTDGTNDN FQQSLEKTAE VESKEDSSLL QNKTNSPFND
LYQMIKKSLD VKTPRKSSAS LLQTPASRFC TPKPGSVQKN DGKPVTSTED IIIPKMDDAK
VFPGADEIKG EVVSISNGTP KSVKKQRKSF QVPPEMAGPA APEHPATSEA TLPQKRNRVS
PQRYTASEVI DQVSAQTSKS PLRRRSKEAT PVKASVTKEQ EEPAMPSPKT KHLQEASPRN
SGKTEKVKDL PKKRKSGELA ADLPTSRMKK KRVSFGGALS PELFDKRLPP DSPLRKGATP
RRSLCLSQPK LSLLRRASVI GFLKEFEDVQ RSPAKKRTPS PKKSSSAKNA SPKTPTPGKK
SPKSKSPSPK AASPGKKSPK SRSPSPKAAS PGKKSPKSRS PSPKAASPGK KSPKSRSSSP
KAASPGTKSP KSRTPSPKTA SAGKKSPKSK TPSPTRGRSP AKSQSKSSTP GRFSVSRIST
PSPVAEDDVT NKMPLVTVTP KIPLRRKSMK STSRKTPSIS RSAVKVMRRS GISRASIKVR
DTWVDVVKFG QTKAQVAAPA KIIVPKKTVK KTVSKPQTPA RKLKGYVSTG HANSPVTIVV
GRAHKQKVVH PTGAAPRVVT NTALFKKNMK MDEDLSGISE MFKTPVNERS RKSVIRDNSA
TETPMGVLSV VDPSVLNTPE EPGEMMVSPL SVASTVKGER YNSEAVQRLL NGDQDSSFIS
EIPALEIHSE SAEQQCTDVK TTHVTTPKQK PEQPECLTGV KRIMKTPRQK AEPVEDLRGK
ILKTPKQKVE QQECLTGVKR IMKTPRQKAE PVEDIRGKLL ATPKQKPEQQ ECLTGVKRIF
KTPQQEAEPL EDLQGKCLQT PRALEAGDVS LDGIEELQKT PAHMQESEDL SEMTDMKTPN
VKSSPLVCLT GVKRIMKTPK EKSAPVEDMV GVKRLMKTPR EKAEPVEENF GIEALMKSPR
LRGNAPVEDF EGLQEVMEEV LTDSPGPLKT DEVEDHPAPP DCGEDIAKEL DFACGEPQDD
TASDVIDNVP QVDMAKETDA NEALVHNHIE EVPSGHDNNE SSDAMETISQ AAVDESLPVE
QPKVDAVDET LSEEQQPEVE TATGKVTELD MNAAAPHHEK KSVRGRRAKT VKSEAAEDKQ
EATEHSEDPV APAPVRGRRG KKTEAPAPST VRQTRRNRNK DVELTLEESA PQSSEVALKP
KRGRNAKKAS EDQVEMVKEV ASETEMVPEV ESNNIPPLDV DHKANDSAAP EEKAVSKPKR
TRKAKQESEQ SVSDVPCDDV PQADVAKDTN EVCSDQLEVV PNENNETKSI AMETVSQAPV
TESLPALVTD TDASVVQKKS VRGRRAKMAE AKTAEDKQEA AINSEDPVVP APLRGRRGKK
TEATAPPAVR QTTRTKNTKS QGSTSDTNPE TQPMTEISTE AVSDQTSQEE DVSASPVEET
DVKPIRGRKS KQKPVEPTQP EPEKSEVLSE EQLMADPQPP VPTVGKPRRG RKTKTDVEQN
EVAEDTVVIE QTKQQSQPPV RAKRGRNAKQ EEEKQENDGK ATSAETLKSQ EPVKKSRRTR
KAEQDNVEPR EDEIQTAEMV FPKEAEAAPV DEPLKMSEQV SVAAKPRRGG RKAQKDTESE
IPVESTEVPA VSSTDKPKRV RRGKQVTEEV DATIEVPEGK PDHELEAEEK KTAEPDVPVI
KPSRARGVKT VKNDVSNAIP AKRARRGAAL PLEETNPEST VQVSESVPTS VEPPKRGRRA
AAKPTTDESA LSCDQANPSE DLSNAVVEDT KKSKRSVKWK AEPEVFQIPK VTPVKAVRGR
RSKLGDQVEP ESKNVSKAAS KTEEKDLSDE VVEAQPIKRA RRGAKVTADT ETSSKVGPKK
GAEAETQPKP RRGRTAKK
//
