ID A0A3B4THB4_SERDU Unreviewed; 2172 AA.
AC A0A3B4THB4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Myosin VIIA {ECO:0000313|Ensembl:ENSSDUP00000005335.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000005335.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000005335.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 41447.ENSSDUP00000005335; -.
DR Ensembl; ENSSDUT00000005437.1; ENSSDUP00000005335.1; ENSSDUG00000003850.1.
DR GeneTree; ENSGT00940000155350; -.
DR OMA; GFQGRCR; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF34; MYOSIN VIIA; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 54..730
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1006..1242
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1247..1555
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1553..1622
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1697..1852
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1858..2161
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 607..629
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 869..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 147..154
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2172 AA; 250659 MW; A2682362899F7F62 CRC64;
LDLKTGREFE VPIGAVVKLC DSGQIQVVDD EGNEHWISPQ NATNIKPMHP TSIHGVEDMI
RLGDLNEAGI LRNLLIRYRE KLIYTYTGSI LVAVNPYQLL PIYTADQIRL YTNKKIGEMP
PHIFAIADNC YFNMQRNNRD QCCIISGESG AGKTESTKLI LQFLAAISGQ HSWIEQQVLE
ANPILEAFGN AKTIRNDNSS RFGKYIDIHF NKRGAIEGAK IEQYLLEKSR VCRQAYDERN
YHIFYCMLKG MTADEKKKLG LSKATDYTYL TMGNCTVCDG RDDLKEYSNI LSAMKVLMFT
DKENWEISKL LAAILHMGNL RYEARTYDNL DACEVVHSPH LTTAATLLEV DGKDLMNCLT
SRTLITRGET VSTPLSKEQA LDVRDAFVKG IYGRLFVWIV EKINAAIYKP PSSQPKALRR
CIGLLDIFGF ENFTVNSFEQ LCINFANENL QQFFVRHVFK LEQEEYNLEH INWQHIEFTD
NQDALDMIAI KPMNIISLID EESKFPKGTD TTMLNKLNFQ HKLNTNYIPP KNNYETQFGI
QHFAGVVYYE TRGFLEKNRD TLYGDIIQLV HSSKNKFIKQ IFQADVAMGA ETRKRSPTLS
SQFKRSLELL MRTLSVCQPF FVRCIKPNEY KKPMLFDREL CVRQLRYSGM METIRIRRAG
YPIRYTFVEF VDRYRVLMPG VKPAYKQEDL RGTCQRIAEA VLGRDDDWQM GKTKIFLKDH
HDMLLEIERD KAITDKVILI QKVVRGFKDR SNFLRMRKSA VLIQKTWRGY HCRKNYGMRA
GFSRLQALVR SRKLCASYHV ARQRITGFQG RCRGFLVRRA FRHRLWAVIT IQAHTRGMIA
RRLYKRLKGE YRRRLEAEKM RLAEEAKLRN QMSAKRAKAE AERKHQERLA QLAKEDAERE
KKEKEEARRK KEMVEQMEKA RLEPVNDSDM VDKMFGFLGT TNSFPGQEGQ APAGFEDLER
THQELEEEDL DEALPLPEDD EEEDLSEYKF AKFAATYFQG TTTHTYVRRP LKQPLLFHDD
EGDQLAALAV WITVLRFMGD LPEPKYHTAI SDGSEKIPVM TKIYETLGKK TYKRELQALQ
GEGETPHSDS HKKNSVRHKL VSLTLKKKSK ITEEVTKRLN DGEHGLHGNS MLEDRPTSNL
EKLHFIIGNG ILRPALRDEI YCQICKQLSQ NPSKSSHARG WILISLCVGC FAPSDKFVKY
LRNFISSGPP GYAPYCEERL RRTFVNGTRT QPPSWLELQA TKSKKPIMLP VTFMDGTTKT
LLTDSATTAK ELCNALSDKV NLRDRFGFSL YIALFDKVSS LGSGNDHVMD AVSQCEQYAK
EQGAQERNAP WRLFFRKEIF TPWHCPADDL VATNLIYQQT VRGVKFGEYR CDRDDLAELA
SQQYYVDYGS EILLERLLSL IPSYIPDREI STSRTVEKWA HFIMAAHKKG IYTQKRFDPQ
KVKEEVVDFA RHKWPLLFSR FYEAFKFSGP SLPKNDLIVA VNWTGVYFVD EQEQVLLELS
FPEITAVSSS RGGKLQGQSF TLATIKGDEY TFTSNNAEDI RDLVVTFLEG LRKRSKFVVA
LQDNPNPTGE ESTFLSFLKG DLILLDQDTG EQVLNSGWAH GINERTNQRG DFPADCVYVL
PTVARPQQEI VALVTMTPDQ RQESVRVSQL VLPETDGKLK PYTLEEFSYD YFRPPPKHTL
SRVMVTKNRG KDKMWSCTRE PLKQPLLKKV VNHEELAQDA CMLFYSLTFV PPMMKYMGDY
PSKRTRSVNE LTDQIFEGAL KAEPLKDEIY CQIIKQLTDN HVKYSEEKGW ELLWLCTGLF
PPSNMLLPHI QRFLQSKKHH PLSGDCMQRL HKALRNGSRK YPPHLVEVEA IQHKTTQIFH
KVYFPDDTDE AFEVESSTKA KDFCQNISTR LLLKSPEGFS LFVKISDKVI SVPEGDFFFD
FVRHLTDWIK KSRPAKDGII PSLTYQVFFM KKLWTNTVPG KDSFADSIFH YYQELPKYLR
GYHKCSREEV FQLAALIYRV KFEDDKSHFP TIPKMLRELV PQDLIRQMSP DDWKRSVVAY
FNKQAGKSRE EAKLMFLKII YKWPTFGSAF FEVKQTTEPN YPEILLIAIN KHGVSLIDPK
SKDILTTHPF TKISNWSSGN TYFHITIGNL VRGSKLLCET SLGYKMDDLL TSYISQMLTT
MNKQRSGRGH SK
//