ID A0A3B4THG6_SERDU Unreviewed; 1296 AA.
AC A0A3B4THG6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Breakpoint cluster region protein-like {ECO:0000313|Ensembl:ENSSDUP00000005483.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000005483.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000005483.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR STRING; 41447.ENSSDUP00000005483; -.
DR Ensembl; ENSSDUT00000005587.1; ENSSDUP00000005483.1; ENSSDUG00000004015.1.
DR GeneTree; ENSGT00940000153491; -.
DR OMA; HLTWPRC; -.
DR OrthoDB; 2916231at2759; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 4.10.280.30; Bcr-Abl oncoprotein oligomerisation domain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR015123; Bcr-Abl_oncoprot_oligo.
DR InterPro; IPR036481; Bcr-Abl_oncoprot_oligo_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF3; BREAKPOINT CLUSTER REGION PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF09036; Bcr-Abl_Oligo; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF69036; Bcr-Abl oncoprotein oligomerization domain; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 525..718
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 735..892
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 919..1046
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1080..1273
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 79..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..55
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 98..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1296 AA; 146302 MW; 8BE8369A6C567270 CRC64;
MVEPVGFVEA WRAQFPESDP PCMELNTLGD IEQELDKCKT SIRQLEKEVN KERFRMIYLQ
TLLAKERKSY DGQRWGFKRM PLTRDGDLPG GTDSQRSHAD EVTAEEQQQR GHVKTVRCKP
HPEGEVDGAS PAKQKGGVSP VRQDSEIPDF PVGTGSVAAL RSNFERIRRA NSHTAGDGRG
LSVMGGQEKP FYVNMEYHHE RGLVKVNDRE VSDKISTLGC QAMQIERKRS LHSLPGNLSA
ATGDISKAVQ RGRSTEGNCS YNGSYDDAEV NPHFLKDSAI RSTGGKSERQ SAECQPYTSV
YVGGMMADGD TRVIHIRDHS IEEEAHLTWP RCSYSPGSFD DVGGGYTPDC SSNENLTSSE
EDFSSGQSSH VSPSPTTYQM YREKSRSPSQ HSQQSFESSS PPTPLSQKHL KQQVIVSEAS
IIGVRKTGQI WPSDGDSTTS SRTSHDNSVQ GDLEAPYNET PPSYGYDLEH SEEHHPRHDP
LSYTGSPSSS PRLRSKSRNS RDTQCSGSLE STLSVELDQE KGLEMRKWVL SGILASEETY
LSHLEALLIP MKPLRAAATT SQPMLTIQQI ETIFFKVPEL HEIHKDFYDA LLPRVQDWSH
QQCVGDLFQK LASQLGVYRA FVDNYKVAVE TADKCCQANA QFAEISENLK VKSTKDCKDQ
LAKNSLETLL YKPVDRVTRS TLVLHDLLKH TPSSHPDHPL LQDALRISQN FLSSINEEIT
PRRQSMTVKK GENRQLMRDR FMVELVEGSR KLRHVFLFTD LLLCTKLKKQ AAGKGQQYDC
KWYIPLADLT FQTIEDCEST PIPLVQDEEI DAMKIKISQI KNEIQREKRT TKGPKVIERL
RKKLSEQESL LLLMSPNMAF RVANRNGKGF TFLISSDYER AEWREMIREQ QKKCFKSFSL
TSLELQMLTN SCVKLQTVHT IPMTMNKEDD ESSGLYGFLN VIVHSASGLK QSLNLYCSLE
VDSFGYFVNK AKTRVYRDST EPNWNEEFEI ELEGSQTLRL LCYEKCCNKS KQSKEEGELT
DKIMAKGQIK LDPQTLQNKD WQRTVITMNG IEVKLSMKFA SREFSLKRMP SRKQSGVFGV
KINVVTKRER SKVPLIVRQC VEEIERRGME EVGIYRVSGV ATDIQALKAA FDSNNKDVSV
MMREMDVNAI AGTLKLYFRE LPEPLFTDEL YPNFAGGIAL SDSVAKESCM LNLLLSLPEP
NLVTFLFLLD HLKRVAENES INKMSLHNLA TVFGPTLLRP SEKDSKISNS SQPISMNDSW
SLEVMAQVQV LLYFLQLESI PTPDSKRQSL LFSTEV
//
