ID   A0A3B4TI53_SERDU        Unreviewed;       804 AA.
AC   A0A3B4TI53;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE   AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000005713.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000005713.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   AlphaFoldDB; A0A3B4TI53; -.
DR   STRING; 41447.ENSSDUP00000005713; -.
DR   Ensembl; ENSSDUT00000005826.1; ENSSDUP00000005713.1; ENSSDUG00000004189.1.
DR   GeneTree; ENSGT00940000154910; -.
DR   OMA; SGCIAIR; -.
DR   OrthoDB; 5404502at2759; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd08544; Reeler; 1.
DR   Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR   Gene3D; 2.60.40.4060; Reeler domain; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR   InterPro; IPR002861; Reeler_dom.
DR   InterPro; IPR042307; Reeler_sf.
DR   InterPro; IPR009465; Spondin_N.
DR   InterPro; IPR038678; Spondin_N_sf.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR044004; TSP1_spondin_dom.
DR   NCBIfam; NF038123; NF038123_dom; 1.
DR   PANTHER; PTHR11311; SPONDIN; 1.
DR   PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR   Pfam; PF02014; Reeler; 1.
DR   Pfam; PF06468; Spond_N; 1.
DR   Pfam; PF19028; TSP1_spondin; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   SMART; SM00209; TSP1; 6.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR   PROSITE; PS51019; REELIN; 1.
DR   PROSITE; PS51020; SPONDIN; 1.
DR   PROSITE; PS50092; TSP1; 6.
PE   4: Predicted;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..804
FT                   /note="Spondin-1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017292357"
FT   DOMAIN          23..191
FT                   /note="Reelin"
FT                   /evidence="ECO:0000259|PROSITE:PS51019"
FT   DOMAIN          191..384
FT                   /note="Spondin"
FT                   /evidence="ECO:0000259|PROSITE:PS51020"
FT   REGION          718..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  90073 MW;  82B4FBCD1CDC96CF CRC64;
     MGMYLHLLLL QYYFVTSFVC NAVAFVEEPS GGRSDGYCGR ILRAPTHGTR KDGHHEFRLR
     VEGDPETYQP GRTYRVVLLA TSPAYFRGFT LIALKEGREG TTDDDYAGQF QIIDEEDTQF
     MTNCPPAVTE STPRRRTRIQ VFWTAPPTGT GCVILKASIV QKKIIYFQEE GSLTIRLCEK
     ERVFGEATGA PALECCACGT AKYRLTFYGN WSEKVHPKDY PRRANHWSAL IGASHSRGYV
     LWEYGGYASE GVRQVAEFGS PIKMEEEIRQ KGDEVLTVIK TKAQWPAWQP LNLRAAPSAE
     FSVDRTRHLM SFLTMLGPSP DWNVGLSGED LCTKECGWVQ RLVTDLIPWD AGTDGGVTYE
     SPNKPTIPQE KIRPLTSLDH PQSPFYDPEG GAITPVARLV VERIARKGEQ CNVVPDTIDD
     IVADIGQEEK EEDDTPETCI YSGWSPWSAC SSATCEKGRR MRQRMLKAQL DLSVPCPHTQ
     DFQPCMGPGC SMEEPSTCMM SEWISWSACS VSCGMGMRSR ERYVKQYPED GSLCQLHTEE
     TEKCVVNDEC SPSSCVVTEW GEWDPCSVTC GMGMRRRERM VKMPPIDGSM CKTEVAEVEK
     CMMPECHTIP CMLSPWSDWS ECSVTCGRGV RTRQRMLKSD PAECSEELEQ TEKCMLPECP
     VDCMVSEWSE WSECNKSCGK GHTIRTRMVK LEPQFGGSTC PETIQRKKCK IRKCRTKTKE
     ERGGGGGGGG GKRRRRGKQG RDAALEEQPA GCRMQPWSSW TDCTKPCGGG IQERFMMVKK
     RAKGALAAGC KDRKEIRACN VHPC
//