ID A0A3B4TKF3_SERDU Unreviewed; 448 AA.
AC A0A3B4TKF3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Caspase 8 {ECO:0000313|Ensembl:ENSSDUP00000006711.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000006711.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000006711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR AlphaFoldDB; A0A3B4TKF3; -.
DR Ensembl; ENSSDUT00000006842.1; ENSSDUP00000006711.1; ENSSDUG00000004716.1.
DR GeneTree; ENSGT00940000166591; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08792; DED_Caspase_8_10_r1; 1.
DR CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF5; CASPASE 10; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..77
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 93..170
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 204..328
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 365..447
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 448 AA; 50910 MW; 884E507D3A5231D2 CRC64;
MDRLKLSHID EELDSSEVAA LRFLCLGIVN RKRMEGIKDA KQLFLRLEEN GLLDNGVFLA
ELLHTIRRAD LLSLLEADSR RPEETDARPT LSPYRVMLYG IYEDMTTENF EKMKFLLSSK
LGRRQIEASN TALDLFVEME KADLLSPTKL NDMHAVLKEF DQQLALTVKR YMDEVRQQNP
TRVPPPPHVS MVFQLCYYDL NHNPRGLCVV INNEKFLGEE LKDRGGTQED ANVLKSVFSR
LGFTVVVHNN LTASRIRSEL RELSKNDFLA HDALVICVLS HGEKGCVFGT DEKKVGLREL
TLPFTSKNAP TLARKPKLFF IQACQGDGYQ EGSVPCPPRP GEEEVRHSRL QEDAGPVRGE
TVAWDADFLM GMATVPECKS FRNTSTGSIY IQELCRQLIR SADSVEMDDI LSVLTRVNRE
VGKGEYLTHK QMPEPKYTLT KKLVLKYV
//
