ID A0A3B4TMD4_SERDU Unreviewed; 1300 AA.
AC A0A3B4TMD4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Rubicon autophagy regulator {ECO:0000313|Ensembl:ENSSDUP00000007414.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000007414.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000007414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 41447.ENSSDUP00000007414; -.
DR Ensembl; ENSSDUT00000007553.1; ENSSDUP00000007414.1; ENSSDUG00000005427.1.
DR GeneTree; ENSGT00940000165727; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd17686; RUN_RUBCN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR048569; RUBC_PIKBD.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF21054; RUBC_PIKBD; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 39..176
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 211..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1265
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1300 AA; 144796 MW; 3E472B2A8B67BA41 CRC64;
MESTVEGEAE ERRREHWKLL SSLKTTVEGL VSTNNPNVWS RYGGLQRLHK DMNNILSHGL
KNEQVYYKQR DYWPFVWCVR YISPQLASHV EQFSHLEPVL SSGMQSAGES YKAERWLLHS
LQVHKLSAQL RPLLRHLGHK RKYYNDDAFL LSEPHVTAMF QCLEAVEQNN PKLLAQVDTV
GLSPLKGPPC LGLLKSQSLC VLPGAGGAWK NRDSAPRGES LNRRLTTSNC SLREAVTPSH
KSGNTTGVES LISNSKNTTS SASNLGAPWV CVSRPGESEW GVTPPPGPVS VPSISLTESP
TPNSLQPETA DSGDGDYDDG PEYLAIGNLG QRSRRDSQSS THSSEHGENP DQSLERSSQA
LPPPRRSSFS EGQRGPGRGS RGHTRSFSDT GINQKLRNES AGDDCCMKDY SPFSTQCSDS
STPSSLYMES HGSQYSSVSD GMFRKPSEGQ SLISYLSEQD FGSCADLEKE NAHFSISESL
IAAIELMKYN LRRQEEEGEE EGDSDCEIQQ LKQKIRLRRQ QIRRSRLPPC TTSQHIFHST
DSGGSRRSSQ DSYQGLSDSG SAEEVEECEL RDGCEGQSLL AVSQNGLSLS LASLFSDADI
KRSVSSSTRS FLSSESISPS FLQSNSAESV AMGLLRQFEG MQLPAASELD WLVPEHDAPQ
KLLPIPDSLP ISPDDGEHAD IYKLRIRVRG NLEWAPPRPQ IIFNIHPAPK RKIVVAKQNY
RCAGCGTRID PDYIKRLRYC EYLGRYFCQC CHENSQAVVP GRVLRKWDFS KYYVSNFARD
LLSKIAGDPL FNPNDINSGL YKKNKALEAV RVLRVQLFHM KNLFKTCRLA KEVLDQFDSL
PGHLTEDLHL FSLNDLTAVR NGELAPRMKE LLKLGTLHVA GCVLCQAKGF VCEFCGNDKD
IIFPFQLNKC QRCEGEPSLL VAGLGGSRAP SPRPFIPLSW RDWKISKPRR LARALSKDRR
EGEGGEEVLE LAVDHGGEQG ERGEMGEEPR HTPKERQERR GIFQAFAPGK LVNIFSRSKG
DEGEHEGQEG GTESEREEER EQKGNDHGKV CSKEGAKKKE RKDGHAKKEK VNLLKVLQID
RLKKSISKGD GCDSDSETCS SMESLDGVGQ ERKGRWKVSG LLNLPKGFSK REQECEGKTE
VKGEESENQF LEKPTGTKEK GKAKWVVEEG NDKQDKGKME AAETVKFKSG AEKGEKVTAM
ELLKPHQLSG VFSRGKSRAE EDKSRESDGK REVETEETGQ KESTTITRSN WRGRKTRKAR
RVTRGRKTRE GTEKESNTDD GESADMNDTD DNTERGGGQE
//
