ID A0A3B4TMF2_SERDU Unreviewed; 429 AA.
AC A0A3B4TMF2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Bone morphogenetic protein 6 {ECO:0000313|Ensembl:ENSSDUP00000007434.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000007434.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000007434.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3B4TMF2; -.
DR Ensembl; ENSSDUT00000007571.1; ENSSDUP00000007434.1; ENSSDUG00000005217.1.
DR GeneTree; ENSGT00940000158768; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19396; TGF_beta_BMP6; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF137; BONE MORPHOGENETIC PROTEIN 6; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 300..429
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 290..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 48842 MW; 103DA5AD1C920911 CRC64;
TYAILWKSAP EFVLSAYYCM FSVAGSNYSL DGNNEVHPGF IQRRLRTHAK REMQREILSI
LGLPHRPRPH LSHGKFNSAP LFMLDLYNTI SSDEKSQVQS MLDGYQSMLT TQSSPLATYQ
ETAFLNDADM VMSFVNLVEY DSELFPQQRH HKEFKFNLSQ IPKGEAVTAA EFRLYKECVS
HTFHNDTFLL KVYQVVKEHS DREADLFLLE SRRLWAAEEG WLEFDITATS NLWLLSPVHN
LGLQVSMETS SGQSISVKEA GLVGRDGALE KQPFMVAFFR ISEVYIRTAR STGGKRRQQN
RNRSTQPQEG SMGLGVADYN NSDQKTACRR HELYVSFREL GWQDWIIAPE GYAANYCDGE
CSFPLNAHMN ATNHAIVQTL VHLMNPENVP KPCCAPTKLH AISVLYFDDN SNVILKKYKN
MVVRACGCH
//
