ID A0A3B4TMM5_SERDU Unreviewed; 956 AA.
AC A0A3B4TMM5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5C {ECO:0000313|Ensembl:ENSSDUP00000007504.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000007504.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000007504.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; A0A3B4TMM5; -.
DR STRING; 41447.ENSSDUP00000007504; -.
DR Ensembl; ENSSDUT00000007644.1; ENSSDUP00000007504.1; ENSSDUG00000005477.1.
DR GeneTree; ENSGT00950000182815; -.
DR OMA; AMNCLEL; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08799; Death_UNC5C; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042154; Death_UNC5C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..956
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017195722"
FT TRANSMEM 397..422
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 176..257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 556..691
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 890..947
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 956 AA; 105994 MW; 3E75D8318B13063C CRC64;
MGYGAQTDRE GGRVPRASPE MLTVSWLLVF LLVDIGVAQV EDDFIGLGEL PETFPSDPPE
PLPVFLMEPE EAYIVKNKPV NLYCKATPAT QIYFKCNSEW VHQKEHTVEE RVDENSGLVV
REASIEITRQ QVEELFGPED FWCQCVAWSS AGTTKSRKAH VRIAYLRKTF DQEPLGKEVS
LEQEVLLQCR PPEGIPAAEV EWLKNEEVID PADDRNFYIT IDHNLIIKQA RLSDTANYTC
VAKNIVAKRR STTATVIVYV NGGWSTWTEW SVCNSRCGRG YQKRTRSCTN PAPLNGGAIC
EGQGIQKLAC NPLCPVDGLW TEWSKWSTCG TECTHWRRRE CSAPAPKNGG KDCEGMVLQS
KNCTDGLCMQ SSLYQKSSEA KDKSDLGNSL APSTDDVALY VGIVIAVIMC LVISVVVALF
IYRKNHRDFD SDIIDSSALN GGFQPVSIKT ARKADLLTAP PDLTSAAAMY RGPVYALHDV
ADKIPMTNSP LLDPLPNLKI KVYNSSGLVT PQDDLGGELS SKLSPKLPHC LLDNSDSTMG
RRTQTQTLLR TRDPSCTALG SFSSQGGHLI VPNSGVSLLI PAGAIPQGRV YEMYVTVQRK
DNMRPSVDDG QTVLSPVVSC GPPGALLTRP VIITMHHCAV CDGQQDWLIQ LKSQSQQNQW
EDIVVVGEEN FTTPCYIQMD DEACHILTET LGTYCLVGQS LSAATTKRLK LAIFGPVTCP
AMEYHIRVYC LDDTQDALKE VLQMEKQMGG KLLDEPKTLN FKDSTHNLRL SIHDVPHTLW
KSKLLAKYQE LSFQQVWDGS QRNLHCCFTL ERFSISTVDL ACKICVRQVE GEGQIFQLDT
TLSEDSQSID TSLLDPASNI TTLVGPNAFR IPVSIRQKLC GSLDAPQTRG NDWRMLAHKL
NLDRYLNYFA TKSSPTGVIL DLWEAQHFPD GNLSRLAQVL EEMGRHDSLV PAATEH
//