ID A0A3B4TMW8_SERDU Unreviewed; 840 AA.
AC A0A3B4TMW8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Spectrin repeat containing, nuclear envelope 2b {ECO:0000313|Ensembl:ENSSDUP00000007347.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000007347.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000007347.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR AlphaFoldDB; A0A3B4TMW8; -.
DR STRING; 41447.ENSSDUP00000007347; -.
DR Ensembl; ENSSDUT00000007486.1; ENSSDUP00000007347.1; ENSSDUG00000005366.1.
DR GeneTree; ENSGT00940000154656; -.
DR OMA; QVMCHLL; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 3.
DR Gene3D; 1.20.58.60; -; 4.
DR InterPro; IPR026696; AKAP6/CEP68.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR14514:SF4; NESPRIN-2; 1.
DR PANTHER; PTHR14514; PKA ANCHORING PROTEIN; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 5.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..789
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 790..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 811..840
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 781..840
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 353..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 96182 MW; 4022A5938AEE752E CRC64;
MSITWHLSFC RVRKLKETLV TVQQLDKNMS NLRTWLSRIE AELAKPVVYN ICHSDEIQRK
LAEQQDLQRD IEQHTESVAS VLTLCDVLLH DADACGSDSE NDSIQQTTRS LDRRWRNICA
MSMERRMRIE ETWRLWCKFL DDYSRFEDWL KTAEFTAANP DSADVLYTSA KEELKKFEAF
QRQVHERLTQ LELVNKQYRR LARENRTDTA SKLKVMVHEG NQRWDSLQRR VAAVLRRLKH
FTSQREDFEG TREGILVWLT EMDLQLTNVE HFSESDIEDK MRQLNGFQQE ITLNTNKIDA
LIVFGENLIQ KSAPLDAVLI EDELEELHSY CQEVFGRVAR FHHRLVNRRP VLEEERDLSD
RDTDLEDSPD LTIGTSWRET RKKEEEVPAV GGVSAGRQAV CHLLAPPLER SGRETPVSVD
SIPLEWDHTV DVGGSSSHED DEDATFFSAL SDVQVTESSE SFVKATVRAV EGASGRHSAC
CIGTHIGCTQ RYSGVKAFPP SDSCLSAGVI QRWELLQAQK FNNETDIKQD LEQWQKLNSD
LCDVTSWLGR VLPELERLQR IAPSTSIRDI EVNIRKLKEM QKSFNSYKCL MISVNLSSRH
FLRGDSVELR ELQEALSSAN LSWTQACGGL ESWERRLHCA LMQCQTLHSL LLWLAQAENK
LFTVNVSDLL TSRSVLLEHR DLHGRQRQVS SLQDISSQLL LEATGEDSVE AKEKVHVIGN
KLHLLLRQVA ADLHALQGKL VGPLYEVTSF NNLLLGEQHP GAGTCSQVTC LEERRDSSPR
RPFFYRVLRA AFPLHLLFLV LLVLACLVPL SEEHYSCTLS NNFARSFYPM LRYTNGPPPT
//
