ID A0A3B4TQV3_SERDU Unreviewed; 4799 AA.
AC A0A3B4TQV3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSSDUP00000008639.1};
GN Name=RYR3 {ECO:0000313|Ensembl:ENSSDUP00000008639.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000008639.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000008639.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR STRING; 41447.ENSSDUP00000008639; -.
DR Ensembl; ENSSDUT00000008802.1; ENSSDUP00000008639.1; ENSSDUG00000006149.1.
DR GeneTree; ENSGT00940000155507; -.
DR OMA; KFCLAVE; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF9; RYANODINE RECEPTOR 3; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50919; MIR; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 94..149
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 156..201
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 264..314
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 573..784
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1214..1425
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1719..1759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4248..4309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4266..4306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4799 AA; 543065 MW; 5F28DAF14E2E9366 CRC64;
VRMGGVGLGE GRDDEVVLQS VATIQKEHRK FCLAAEGLGN RICYLESTSE AKYVPPDLCI
CNFVLEQSLS VRALQEMLAN TGQSSEGAGQ GGGHRTLLYG HAILLRHSFS SMYLTCLKTS
RSLTDKLSFD VGLQEDSIGE SCWWTIHPAS KQRSEGEKVR IGDDLILVSV STERYLHLSI
SNGNIQVDAS FMQTLWNVQP TCSSGYLIGG HVMRLCHGHD ESLTIPGADK NEEEQRIVNY
EAGKGASRAR SLWRLEPLRI SWSGSHIRWG QAFRLRHLST GHYLALTEER GLVLQDREKS
DTTATAFCFR ASKVGEKGDS GPKRDIDGMG VPEIKYGDSV CFIMHLATGL WLSYLAPDAK
SSRLGPLKRR ACLHSEGHMD DGLTLQRCQH EESRAARIIR NTTFLFTNFI NTAEGESTAV
AGYVEEVLQT LNDLIQYFKQ PDSELEHEEK QCLLRSLIKR QDLFKEEGML ALLSKCIDRM
NLYNSAAHFG EMAGEEAGAA WKDILNLLYE LLASLIRGNR NNCTQFSRNL DWLISKLERL
ESSSGILEVL HCILVESPEA LNIIQRGHIK SIISLLYKHG RNHKILDVLC SLCVCNGVAV
RANQNLICDN LLPKRDLLLQ TRLVNDVQSM RPNIFLGMAE GSAQYKKWYF ELVIDQVDHF
VTGEPTHLRV GWANTKGYAP YPGGGEGWGG NGVGDDLYSY SFDGLHLWSG RIPRAVASIN
QHLLNSDDVV SCCLDLGAPS MSFRINGQPV QGMFEDFNTD GFFFPVVSFS AGVKVRFLLG
GRHGDFKFLP PAGYSPCYEA LLPKEKMHVE PVKEYKRDHE GVRDLLGTTQ FLSQASFIPT
PVDTTQIVLP PHLDNVRDKL AENIHELWGM NKIELGWTYG KVRDDNKRQH PCLVDFAKLP
ETERNYNLQM SSETLKTLLA LGCHVAQVNV HAEDDLKKIK LPKDYMMSNG YKPAPLDLSD
VKLNAGQEVL VDKLAENAHN VWAKDRIKQG WTYGIQQDLK SRRNPRLVPY ALLDERTKKS
NRDSLREAIR TMVGYGYDID PPDQEGETLL IETIRFFRVE QTYAVKTGKW YFEFESLTGG
DMRVGWARPG CRPDVELGVD DQAFGRRMHV GSRYFGHPWK KGDVVGCMIN MEDKSMIFTL
NGELLITNKG SELCFADFET EDGFIPVCSL GMSQIGRMNL GKDANTFKYY TMCGLQEGFE
PFAVNMNREI TMWFSKRLPT FVNIPQDHMH VEVTRIDGTV DSPPCLKVTH KTFGTQNSNN
DMVYCRLSMP VEFYSADKLL EESLKLSNQL YSVVFAGQDP ASVWVGWVTP DYHYHSKSFG
LSKTRTVTVT LGDERGRVHE SVQRSNCYMV CGADAVGPSS SNRSNSDLEI GCLIDLATGL
VSFTANGKEL PTTYQVEPNT KLFPSVFVRP TSPNLFQFEF VKIKDAMPLS SAIFKSEHRN
PVPQCPPRLD VQTIVAVLWS RMPNTFLTVE TARVSERHGW VVQCLEQLQI MAVHIPEENR
CLDILELSEH EDLRKFHYHT LKLYCALCAL GNTRVAHALC SHLDQSQLLY TIDNQYLSGM
LREGFYNVLI SIHLETAKEA RLMMNNEFII PVTDETRSIK LFPDESKRHS LPGVGLSTSL
KPRVNFSPVG IINTKRHQYL YSPQIPLVIL KEKAISMLTE AVQGGGTHIR DPVGGSAEYQ
FVPILKLIGT LLIMGVLTSE EVRLILLLID PNVFGEATEG EEGKADEVAE AGEKEEVSKN
EEKAVEAGEE ETKESKAPAK GLLEKSLPES VKRQMCELLH YFCDCELKHR IESIVSFSDS
FVSKLQFNQK FRYNELMQAL NMSAAVTAKK TKEFRSPPQE QINILLNFSA GEDCPCPEEI
QDELNSFHEE LRLHCGIPVE EEEEEQDTSI KGRLLALLYK IKGPPQKTEE EPTETEQAAP
TNLKELISQT ITSWAQESHI QDPELVRVMF SLLRRQYDGI GELLRAMKKS YTISAASVQD
AINLLASLGQ IRSLLAVRMG KEEEKLMIDG LGDIMNNKVF YQHPNLMRVL GMHETVMEVM
VNVLGGDKSQ IAFPKMVASC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASEAMRG
STPLDVAASS VMDNNGLALA LEEPDLEKVV TYLAGCGLQS CAILVAKGYP DLGWNPIEGE
RYLSFLRFAV FCNGESVEEN ANVVVKLLIR RPECFGPALR GEGGQGLLTA MKEAIKISED
PALDLPKTSA GVTTASGEEE GEIIHMGNAI MSFYSALIDL LGRCAPEMHL INAGKGEALR
IRAILRSLVP TTDLVGVISI PLKMPVVNKD GTVTEPDMSA SFCPDHKAPM VLFLDRVYGI
EDQSFLLQML EVGFLPDLRA SASLDTVLST TETALAMNRY IGSALLPLLT RCAALFGNTE
HYAQLIDSTL QTIYRLSKGR SLTKAQRDAI EECLLAICKH LRPSMMQQLL RRLVFDVPML
TEYCKIPLRL MTNHYEQNWK YYCLPSGMGS FGIASEEELL LTKKLFWGIF DSLSHKKYDA
ELFKMAKSCL CAIAGALPPD FVDASLGATL EKQASVDAQG NFDPKPTNTA NISLPEKLEY
IANKYAEHSH DKWSSEKVSA GWKNGDSVDE QAKTHPLLKP YKSLSEKERE TYRWPVRESL
KSMLAMGWNI ERTKEGEVMF QQRESEKQRK ISESQVNGFS PAPMDLHNVT LSRELQGMVE
VVAENYHNIW AKKKKTELVS KGGGTHPLLV PYDTLTAKEK YRDREKAQDL FKFLQISGYA
ITRGLKEMEQ DSSSMEKRFS FKFLKRLLKY IDSAQEFIAH LEAMATSGKT DKSPHDQEIK
FFAKVLLPLT DQTFRNHCLY FLSTPSKSFS SCGCASNKEK EMVTSLFCKL AALVRHRISL
FGSDSAMMVS CLDILTHSLD TRTVMKSGAE LVKAGFKTFF ENAAEDLEKL VEMLKLGKFM
QSRAQMKSVS QSINYVTVAL LPILTALFDH IRTYEFGVDL LLDDVQLSCY RILTCFYCLG
TGKNVFVERH LPALGESLAT LVGAIPVAFL EPHLNAHNPL SVFNTKTPRE RAILSMPDTV
EEMCPEMPSL DRLLKDVNDV SESGARYSDM PQVIEVILPM LCNYLSYWWE KGPESSPPGS
QCCTMVTSEH LSIILGNILR ILNNNLGIDD APWMKRIAVY SQPIICKAGA DLLRTHFLPT
LDKLKKKTVK VVAEEELLKA DSKGDNQEAE LLILDEFAVL CRDLYAFYPM LIRYVDNNRS
RWLKEPDADS TELFRMVAEI FILWCKSHNF KREEQNFVVQ NEINNLGFLT GEGKAKMSKS
GGDQERKHKR RRGEYYSIQT SLIVAALKKM LPIGLNMCTP GDQELISLAK IRYSLKDTDD
EVKEHLRQNL HLQDKSDDPA VQWQLDLYKD VVLKSDLPID SEHTVVRVQS ISAAVFHLEQ
VEQPLRNKKC VWQKLLSKQR KRAVVACFRM APLYNLPRHR AINLFIPAYE RLWIEAEEYS
FEEKLVQDLA KTPMKIVEEE EEEVAEIQPD PLHQLILHFS HNALTERSYL EEDPLYIAYA
DMMAKSCAED EEEEEEEGKE KTFEEKEMEK QKILYQQARL HARGAAEMVL QMISASKGRL
GPMVTCTLKL GISILNGGNV QVQQKMLVYL KEKRDAGFFK SLSGLMQSCS VLDLNAFERQ
NKAEGLGMVT EEGSSKYIFS QGSKVLQNDE FTKDLFRFLQ LLCEGHNRDF QNFLRTQTGN
TTTVNIIIST VDYLLRLQES ISDFYWYYSG KDVIDDTGKI NFSKALSVAK QIFNSLTEYI
QGPCIGNQQS LAHSRLWDAV VGFLHVFANM QMKLSQDASQ IELLKELMDL QKDMVVMLLS
LLEGNVVNGT IGKQMVDTLV ESSNNVEMIL KFFDMFLKLK DLTTSDNFKE YDPEFKGIIS
KKEFQKSMES QKQYSQSEID FLLSCAEADE NDMFNYKEFV ERFHEPAKDI GFNVVVLLTN
LSEHMPHDSR LATFLDLAES VLSYFEPYLG RIEIMGSAKR IERVYFDISE SSREQWEKPQ
VKESKRQFIF DVVNEGGESE KMEMFVNFCE DTIFEMQLAS QISEPDEVEQ PEEEEDEDGH
SILEELAAEE GGALESASAF STACCAVKKK VAHVRQIFSI KNVRKQFKKI KKLTIKEIIT
GFFSFFWMLF TGFFKGIYSL IFGFFHVIWS SMFGGGLVEG AKNIKVTDIL GNMPDPTQFG
IHGDVIEGEK VEAIESSGNL DIAMAPAGDI AEVDMMLEML TMPKKEGGKH LEPGLGDVSE
LSAETSTTDQ KKKKQSDTEN QEKEDKPKEE EAKEPVTEEK PKTRLSQAKE PAPAFMSNIF
AALDIYLTKM LNYLARNFYN LRFLALFVCF AINFILLFYK VTKAELQPLD TDDENQWGEE
EEDQDTLFDM DEFVLQESTG YMLPTLRFLA IFHTVISLLC VVGYYCLKVP LVVFKREKEI
ARKLEFDGLY ITEQPSDDDI KGQWDRLVIN TPSFPNNYWD KFIKRKVINK YGDMYGAERI
AELLGLDKSA LDFDPTVETE EREASLVSWL SSIDTKYHIW KMGVVLTDNS FLYLIWYTTM
SIFGHFNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF
FRKFYNKSED EDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DELEDPAGDP YELYRILFDI
TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGNDYF DRTPHGFETH
TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPTGDCF RKQYEDQLG
//
