ID A0A3B4TRB4_SERDU Unreviewed; 4362 AA.
AC A0A3B4TRB4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=FAT atypical cadherin 2 {ECO:0000313|Ensembl:ENSSDUP00000008577.1};
GN Name=FAT2 {ECO:0000313|Ensembl:ENSSDUP00000008577.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000008577.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000008577.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 41447.ENSSDUP00000008577; -.
DR Ensembl; ENSSDUT00000008736.1; ENSSDUP00000008577.1; ENSSDUG00000006306.1.
DR GeneTree; ENSGT00940000158507; -.
DR OMA; QRRENCT; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 32.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24026:SF126; CADHERIN-RELATED TUMOR SUPPRESSOR; 1.
DR PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR Pfam; PF00028; Cadherin; 31.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..4362
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017229594"
FT TRANSMEM 4058..4084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..151
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 152..259
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 363..458
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 459..564
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 572..671
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 709..813
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 814..918
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 919..1025
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1026..1130
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1131..1234
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1235..1346
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1373..1438
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1439..1544
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1545..1649
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1650..1747
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1748..1861
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1862..1957
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1958..2059
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2060..2160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2161..2261
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2262..2368
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2369..2470
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2471..2574
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2575..2681
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2682..2787
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2788..2899
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2900..3005
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3006..3107
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3108..3212
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3213..3316
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3317..3421
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3422..3526
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3545..3637
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3765..3945
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3947..3984
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3986..4022
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4135..4188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4316..4362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4145..4166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4320..4334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4335..4350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3974..3983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4012..4021
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4362 AA; 481213 MW; 87BEF5684F558F8D CRC64;
MAASGTTLLT LAALLLHVAR CQGIMGKGKD SSPLRFTHHL YNATINENSA PRTYVETPLK
MGIEVTDLFW EITYNVVSGD DDGLFQAESV KVGDFCFLRI KTRSSNSALL NREVRDTYTL
TVEATESTFD FQVKTKVFVQ VLDTNDLKPL FYPASYNVGI REDTPLRSSV VRVSATDADI
GSNAEFYYSF TSRAHPFVVD PFTGTVSLIK KLNHTRSERY DLTVLAEDRT KKISGVQKFG
NVARVTVNVQ KMSMGSPVIT TSPKPTVSTD GKITINVHVE AGVKSVESLN IVEGDPHKCF
EIIPLGVQGS DFQVISTKRI IWSQTPFGLN LSLQAKDRSA PSLVSPIAQI HIPAYHYSPL
AFLEDTYIVT LSEFSPPKTH VLKVSVTAVP YNVTFSIKNN PESSNFKINP KTGIIITTEK
FDYERKDRYE FDVLANHGEA ETHIVVEITD ENDNSPQFSQ TSYQATVDEN TPVGSSVLKV
AATDKDKGKN GFVTYAIANS GPLPFTIDPF TGVISTSEHL DYELMKRRYH LRVWASDSGS
PFSQVSECPV TITLNNINDN IPLFERVGCN TTVPQDLPVG YTICELSAID LDELQQLKYV
IESGNELQVF GIDSLSGAIT LKQPIPLRAG SFTLRVVATD GKHHSDASVV RITVTNRGDE
VTLHCQETGV FKELTDKLIE SIKPILTSQE EDTFSDIHIT NRHSPKFDPS IPSSIDLIED
HPLNSTILQF KATDNDTGFN SKLVYAISSG NEDGCFSIDT FSGDLQLVCP LDRESKEFYI
LNITVYDLGT PQTSAWKFIA VNIMDVNDNP PVFDQPRYVI RVPENTEVDS IIFTARAIDL
DAETSGNVQY SLMTSTDMFR IDELTGEVIV TRHLDRETSP RHDLQIEARD QARVSPQLFS
MIDLVVVLQD INDNPPKFVP KVYKIKVPED VPVGTLLVWV ESVDLDLGSG GLVTYNLKNT
ESGIFHVDSS TGALTLERDL DFERRPSYNL TVRAVDHGLP RSLSSSCFVE IQVLDVNENL
YRPVFSEFVY EARVMEDAAV GTSVVTLTAA DKDLGRDGVV RYHIHEGSGL GVFTIDEETG
VIRTTETLDR ETMPHYWLSV YATDLGTEPL ISWTHVFLEV LDVNDNAPEL SQPVYFASVQ
ENVDMVKSVV QVSAKDVDTS SEGKLSFQML ESHRTYFDVD PKTGVISTLS ALDREDKSEH
SIEVIVSDNG SPSLRSTATV VIRVLDANDK RPKFTDKLFH VRLPEQHHQA GKQEVCRMVA
RDDDEGSNAV VTYKLQDNTD ERFEIDPVTG VVTSHGDFWP GNYSILTIKA TDQGSPSQSS
TARLDIEWMG HPPPSAEPIT FDEPHFTFAV METEPVTYMV GIIMTETHRL SWFDIIGGDE
EKDFDIQRNS GTISIARRLD AARRSNYNLT VRVSDGHHSA TTQAYIRVVD MNEHRPVFLK
PLYEVRVPED TSPWKDILQI SAEDADTNSK LVYSIHSSLH PDSTKFFHLD PKSGVLVMTE
ELDYEMISVH TLIVMVRDQE IPVKRNFVKV VVHVEDCNDH SPSFLSPRYE ASISNLAPTG
SEVVHVKALD KDMGSNADIS YSLHSGNIDN IFSIDPEMGS ISVSKPLDLQ PQDQFHLTVK
ATDQGFPQRS DICSIHVHIR VSDQTPPAFP SDEYLAEISE LSTFRTPVVT ISASSPAALH
YGIESGDPNG TFHINPYTGL ISTQKHLDFE SCASYKLKVT ASTTAGASSK TVVYIYVIDE
NDNAPVFQQR EYLGQISESS HINSMVMGER NTPLVIQASD ADRDANSMLV YQILEPEALK
VFKIDSSMGT ISLISPVDFE ARAKYHFTVQ VKDSGEPSLY AAEPAKVTVH ILDLNDCPPQ
FTTPVYEPSI IFPTVRDTEV VRVMAHDADS TVSYSITEGN LHNAFSIHPS TGVISMSNVS
EFRPFYQLVV KASDGLYKDS ATVIVNVTNL TASDLGFEQK VYSASITENL KTVKILAALK
ATGCYLNEPL LYSVVNPMER FAISQTSGVL ETTGVPFDRE EKDLYDVVVK VQDMRTPPRT
ATTQVKVFID DVNDNSPQFL NLPFSMMISE DSEPGDVLYQ VTAIDRDLGE NGSIMYSLEE
DYDLFRIDPD VGDVSLQRPL DFEALNKYAL TVLAIDEGEP THSTVAQLTI QVRNRTNPVF
QTLLYPLKVP ENVPPFTTIL HVQARNPEGY RLIYNLEEEN ASKHFHIDFK TGVLTVTNPL
DYESQTMHVL TVRATDSVTG AFSEASVEIE VEDVNDNPPV FSKLMYRVSI PEGLPVGTSV
IQLSASDRDS GRNKDLTYKM VKTEGNETDF FEIDPQSGLI FTKQVLDHEN TKHFNLKIKA
TDNGTVPLSS EASVFVNVTD VNDNPPDFVS SQYEATLDEM AKCGHIVIKI QASDPDTGDL
NNLKYKILSG NEGRYFNINE SSGIISFSNV CKRNLDPYYN LTVAVSDGVF QKTAPVNIDM
INSNRHSPYF KQSIYEAELA ENAEAGTRVI RLAAIDPDDG PYGSVDYTII NKLADEKFAI
DNNGQIVTTQ PLDRENPAQR VIAIKVMAKD GGGKVAFCTV KIILTDENDN VPQFKASEYQ
VSIQSTVNKG SPVIQIMAYD ADDGKNADVT YTVDETEEVT EDIIEINPFT GVVSVKESLV
GMENKIFNFK VKARDGSLPF YNSTVPVQVK VVPPEVPLPK FSEPLYTFSA AEDIPIGTEI
GSVRADSDMP LIYSLVNGNT VESNKDKVFT LDKESGTLLL QKTIDHEKTK WYQIDVIAQG
NHNGTDVASL VSVSIQVQDV NDNQPVFDAS PYRAFLAENM PAGTTVIQVT ANDPDTDTNG
LVTYSLESLP DGTATDITNV FSIDGESGWI TTAQETDCEA TRVYRFSVVA TDHGGDNKLS
SSVLVEVTVT DENDNPPKFS DEVYRGSVVE NSSPGEVIIS MTTTDADVSL ENRLVTCYIT
GGDPLGQFAI IQEDEGEWGL IVKERLDRET KDRYTLKVTA TDGKFEAPVT VDVHVLDIND
NSPLCEQLVY TEVVMENSPS SMFVLKVSAS DPDVGANGQI SYTLHGPDAD KFHLNHRTGE
LFTLAVLDRE REVEYNLVAK ATDGGGRSCQ ADILLMIQDM NDNPPRFSSS HYEVTVFDNT
TIRTPIAVIY AKDPDTGINS EVKYSLLAGD SGYFSLDEFS GILRLERPLT PDTPPTFELK
VKATDRGLPR HLYSIATVTV DVVSLDDYQP VFLSSEYTAQ LRESLAVGSE VLSVSALTRD
GGGPDHVVYR IISGNEDGRF QLDSQTGLLL LIAPLDFEVS REYYLSVEGS RGKSSLSDIT
TVIINVTDVN DNTPAFGRGD YSTEISEDLT PGSLVMKVTA TDEDGPINNL LRYSIVSGDP
LQQFIIHPRS GEITVRTSVD REEITHYSLT VQAADEGDPP LSSAVLITIT ITDVNDNPPV
FSQVNHSLLL QEGESLGSSI LQLVVTDKDT PKNGPPFSFH IVSGNEERRF HIDQGGLLSL
SAPLRKKVKP YHQLKIQVTD SGHPPLSSIC VVNINVTEQS KYPPSVVPLE VFITTSGGLF
ANRVIGRLHA SDQDLQDVLT YKLVSENPDG GRFSVDLADG KIWADENLKE GSYSLNVSVT
DGKFSVWTGV KVHVWAADQK ALDSGLTLQL VGMSPEEFLG DHWRGLQRSL GQALGLPRQE
LHLASLQQQH DTQVLEALLI WKPQSGLVQS LPTNRLAGII SDIEDSLGLS ILRVSHNGCL
GTSCPPRGCR NAVRLTGERL GHFTTARAGY ITPQHTWESV CPCNESAVRF DGKSYLKYLH
RMDEDNQNFK LSLRFKTFQE QGLIVSTNST NDWGVLQLTS GELHFSYSCG RTPPGSLVIR
SDPVSDGRWH GILLEVNSTT LRLTLDEQHP TSTTLTEPCR MMHSHGALLF ASLAQDSAPE
VHGQPRSFIG CLEGLEFNGE PIRVGDIAEW TGSGSRRVFG VYQCCSRAGA CDNNPCQNGG
VCEEDAIGEP RCRCAGLFHG AHCKLPDNPC ASQPCAHGRV CVPKAHGYMC NCSLDDAEAR
CHNQIEVCSP NPCPGGFDCK VTDGSIHCDP LPQKVIPMIG YVEIMEISAS VLGLLFLVGI
FVCIRKRYVQ QKKKKPVCVQ DSNGYFQPSL AKSLKADNQD VNPIEMSSLV GPTNDLDHTP
FRSLRPHSQI GSSGGGVSSA KTQGPVVCSV APNLPTRPPS SSDNDSIRKS HWDMDYEVYP
ADPDYYGRPT VQEFPQFDIV EDTYSTSTME SRRNSRFGGF PFPLDRCDRR APLPPCYSNQ
NLDDFLGPDG LPLPSSQCPN EYTAISYYPT QHTRSLDNVS GGYKRLSMRL SVAMPSYAEQ
ASPPPAPNPA QPQTRPTGQN PRSYDGSSMV GSDYGSCEEV MF
//