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Database: UniProt
Entry: A0A3B4TRB4_SERDU
LinkDB: A0A3B4TRB4_SERDU
Original site: A0A3B4TRB4_SERDU 
ID   A0A3B4TRB4_SERDU        Unreviewed;      4362 AA.
AC   A0A3B4TRB4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=FAT atypical cadherin 2 {ECO:0000313|Ensembl:ENSSDUP00000008577.1};
GN   Name=FAT2 {ECO:0000313|Ensembl:ENSSDUP00000008577.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000008577.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000008577.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   STRING; 41447.ENSSDUP00000008577; -.
DR   Ensembl; ENSSDUT00000008736.1; ENSSDUP00000008577.1; ENSSDUG00000006306.1.
DR   GeneTree; ENSGT00940000158507; -.
DR   OMA; QRRENCT; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 32.
DR   CDD; cd00054; EGF_CA; 1.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.60.40.60; Cadherins; 33.
DR   Gene3D; 2.10.25.10; Laminin; 2.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR24026:SF126; CADHERIN-RELATED TUMOR SUPPRESSOR; 1.
DR   PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR   Pfam; PF00028; Cadherin; 31.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 33.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 33.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   PROSITE; PS00232; CADHERIN_1; 12.
DR   PROSITE; PS50268; CADHERIN_2; 33.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..4362
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017229594"
FT   TRANSMEM        4058..4084
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          37..151
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          152..259
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          363..458
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          459..564
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          572..671
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          709..813
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          814..918
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          919..1025
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1026..1130
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1131..1234
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1235..1346
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1373..1438
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1439..1544
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1545..1649
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1650..1747
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1748..1861
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1862..1957
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1958..2059
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2060..2160
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2161..2261
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2262..2368
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2369..2470
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2471..2574
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2575..2681
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2682..2787
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2788..2899
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2900..3005
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          3006..3107
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          3108..3212
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          3213..3316
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          3317..3421
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          3422..3526
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          3545..3637
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          3765..3945
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          3947..3984
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          3986..4022
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          4135..4188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4316..4362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4145..4166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4320..4334
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4335..4350
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        3974..3983
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        4012..4021
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   4362 AA;  481213 MW;  87BEF5684F558F8D CRC64;
     MAASGTTLLT LAALLLHVAR CQGIMGKGKD SSPLRFTHHL YNATINENSA PRTYVETPLK
     MGIEVTDLFW EITYNVVSGD DDGLFQAESV KVGDFCFLRI KTRSSNSALL NREVRDTYTL
     TVEATESTFD FQVKTKVFVQ VLDTNDLKPL FYPASYNVGI REDTPLRSSV VRVSATDADI
     GSNAEFYYSF TSRAHPFVVD PFTGTVSLIK KLNHTRSERY DLTVLAEDRT KKISGVQKFG
     NVARVTVNVQ KMSMGSPVIT TSPKPTVSTD GKITINVHVE AGVKSVESLN IVEGDPHKCF
     EIIPLGVQGS DFQVISTKRI IWSQTPFGLN LSLQAKDRSA PSLVSPIAQI HIPAYHYSPL
     AFLEDTYIVT LSEFSPPKTH VLKVSVTAVP YNVTFSIKNN PESSNFKINP KTGIIITTEK
     FDYERKDRYE FDVLANHGEA ETHIVVEITD ENDNSPQFSQ TSYQATVDEN TPVGSSVLKV
     AATDKDKGKN GFVTYAIANS GPLPFTIDPF TGVISTSEHL DYELMKRRYH LRVWASDSGS
     PFSQVSECPV TITLNNINDN IPLFERVGCN TTVPQDLPVG YTICELSAID LDELQQLKYV
     IESGNELQVF GIDSLSGAIT LKQPIPLRAG SFTLRVVATD GKHHSDASVV RITVTNRGDE
     VTLHCQETGV FKELTDKLIE SIKPILTSQE EDTFSDIHIT NRHSPKFDPS IPSSIDLIED
     HPLNSTILQF KATDNDTGFN SKLVYAISSG NEDGCFSIDT FSGDLQLVCP LDRESKEFYI
     LNITVYDLGT PQTSAWKFIA VNIMDVNDNP PVFDQPRYVI RVPENTEVDS IIFTARAIDL
     DAETSGNVQY SLMTSTDMFR IDELTGEVIV TRHLDRETSP RHDLQIEARD QARVSPQLFS
     MIDLVVVLQD INDNPPKFVP KVYKIKVPED VPVGTLLVWV ESVDLDLGSG GLVTYNLKNT
     ESGIFHVDSS TGALTLERDL DFERRPSYNL TVRAVDHGLP RSLSSSCFVE IQVLDVNENL
     YRPVFSEFVY EARVMEDAAV GTSVVTLTAA DKDLGRDGVV RYHIHEGSGL GVFTIDEETG
     VIRTTETLDR ETMPHYWLSV YATDLGTEPL ISWTHVFLEV LDVNDNAPEL SQPVYFASVQ
     ENVDMVKSVV QVSAKDVDTS SEGKLSFQML ESHRTYFDVD PKTGVISTLS ALDREDKSEH
     SIEVIVSDNG SPSLRSTATV VIRVLDANDK RPKFTDKLFH VRLPEQHHQA GKQEVCRMVA
     RDDDEGSNAV VTYKLQDNTD ERFEIDPVTG VVTSHGDFWP GNYSILTIKA TDQGSPSQSS
     TARLDIEWMG HPPPSAEPIT FDEPHFTFAV METEPVTYMV GIIMTETHRL SWFDIIGGDE
     EKDFDIQRNS GTISIARRLD AARRSNYNLT VRVSDGHHSA TTQAYIRVVD MNEHRPVFLK
     PLYEVRVPED TSPWKDILQI SAEDADTNSK LVYSIHSSLH PDSTKFFHLD PKSGVLVMTE
     ELDYEMISVH TLIVMVRDQE IPVKRNFVKV VVHVEDCNDH SPSFLSPRYE ASISNLAPTG
     SEVVHVKALD KDMGSNADIS YSLHSGNIDN IFSIDPEMGS ISVSKPLDLQ PQDQFHLTVK
     ATDQGFPQRS DICSIHVHIR VSDQTPPAFP SDEYLAEISE LSTFRTPVVT ISASSPAALH
     YGIESGDPNG TFHINPYTGL ISTQKHLDFE SCASYKLKVT ASTTAGASSK TVVYIYVIDE
     NDNAPVFQQR EYLGQISESS HINSMVMGER NTPLVIQASD ADRDANSMLV YQILEPEALK
     VFKIDSSMGT ISLISPVDFE ARAKYHFTVQ VKDSGEPSLY AAEPAKVTVH ILDLNDCPPQ
     FTTPVYEPSI IFPTVRDTEV VRVMAHDADS TVSYSITEGN LHNAFSIHPS TGVISMSNVS
     EFRPFYQLVV KASDGLYKDS ATVIVNVTNL TASDLGFEQK VYSASITENL KTVKILAALK
     ATGCYLNEPL LYSVVNPMER FAISQTSGVL ETTGVPFDRE EKDLYDVVVK VQDMRTPPRT
     ATTQVKVFID DVNDNSPQFL NLPFSMMISE DSEPGDVLYQ VTAIDRDLGE NGSIMYSLEE
     DYDLFRIDPD VGDVSLQRPL DFEALNKYAL TVLAIDEGEP THSTVAQLTI QVRNRTNPVF
     QTLLYPLKVP ENVPPFTTIL HVQARNPEGY RLIYNLEEEN ASKHFHIDFK TGVLTVTNPL
     DYESQTMHVL TVRATDSVTG AFSEASVEIE VEDVNDNPPV FSKLMYRVSI PEGLPVGTSV
     IQLSASDRDS GRNKDLTYKM VKTEGNETDF FEIDPQSGLI FTKQVLDHEN TKHFNLKIKA
     TDNGTVPLSS EASVFVNVTD VNDNPPDFVS SQYEATLDEM AKCGHIVIKI QASDPDTGDL
     NNLKYKILSG NEGRYFNINE SSGIISFSNV CKRNLDPYYN LTVAVSDGVF QKTAPVNIDM
     INSNRHSPYF KQSIYEAELA ENAEAGTRVI RLAAIDPDDG PYGSVDYTII NKLADEKFAI
     DNNGQIVTTQ PLDRENPAQR VIAIKVMAKD GGGKVAFCTV KIILTDENDN VPQFKASEYQ
     VSIQSTVNKG SPVIQIMAYD ADDGKNADVT YTVDETEEVT EDIIEINPFT GVVSVKESLV
     GMENKIFNFK VKARDGSLPF YNSTVPVQVK VVPPEVPLPK FSEPLYTFSA AEDIPIGTEI
     GSVRADSDMP LIYSLVNGNT VESNKDKVFT LDKESGTLLL QKTIDHEKTK WYQIDVIAQG
     NHNGTDVASL VSVSIQVQDV NDNQPVFDAS PYRAFLAENM PAGTTVIQVT ANDPDTDTNG
     LVTYSLESLP DGTATDITNV FSIDGESGWI TTAQETDCEA TRVYRFSVVA TDHGGDNKLS
     SSVLVEVTVT DENDNPPKFS DEVYRGSVVE NSSPGEVIIS MTTTDADVSL ENRLVTCYIT
     GGDPLGQFAI IQEDEGEWGL IVKERLDRET KDRYTLKVTA TDGKFEAPVT VDVHVLDIND
     NSPLCEQLVY TEVVMENSPS SMFVLKVSAS DPDVGANGQI SYTLHGPDAD KFHLNHRTGE
     LFTLAVLDRE REVEYNLVAK ATDGGGRSCQ ADILLMIQDM NDNPPRFSSS HYEVTVFDNT
     TIRTPIAVIY AKDPDTGINS EVKYSLLAGD SGYFSLDEFS GILRLERPLT PDTPPTFELK
     VKATDRGLPR HLYSIATVTV DVVSLDDYQP VFLSSEYTAQ LRESLAVGSE VLSVSALTRD
     GGGPDHVVYR IISGNEDGRF QLDSQTGLLL LIAPLDFEVS REYYLSVEGS RGKSSLSDIT
     TVIINVTDVN DNTPAFGRGD YSTEISEDLT PGSLVMKVTA TDEDGPINNL LRYSIVSGDP
     LQQFIIHPRS GEITVRTSVD REEITHYSLT VQAADEGDPP LSSAVLITIT ITDVNDNPPV
     FSQVNHSLLL QEGESLGSSI LQLVVTDKDT PKNGPPFSFH IVSGNEERRF HIDQGGLLSL
     SAPLRKKVKP YHQLKIQVTD SGHPPLSSIC VVNINVTEQS KYPPSVVPLE VFITTSGGLF
     ANRVIGRLHA SDQDLQDVLT YKLVSENPDG GRFSVDLADG KIWADENLKE GSYSLNVSVT
     DGKFSVWTGV KVHVWAADQK ALDSGLTLQL VGMSPEEFLG DHWRGLQRSL GQALGLPRQE
     LHLASLQQQH DTQVLEALLI WKPQSGLVQS LPTNRLAGII SDIEDSLGLS ILRVSHNGCL
     GTSCPPRGCR NAVRLTGERL GHFTTARAGY ITPQHTWESV CPCNESAVRF DGKSYLKYLH
     RMDEDNQNFK LSLRFKTFQE QGLIVSTNST NDWGVLQLTS GELHFSYSCG RTPPGSLVIR
     SDPVSDGRWH GILLEVNSTT LRLTLDEQHP TSTTLTEPCR MMHSHGALLF ASLAQDSAPE
     VHGQPRSFIG CLEGLEFNGE PIRVGDIAEW TGSGSRRVFG VYQCCSRAGA CDNNPCQNGG
     VCEEDAIGEP RCRCAGLFHG AHCKLPDNPC ASQPCAHGRV CVPKAHGYMC NCSLDDAEAR
     CHNQIEVCSP NPCPGGFDCK VTDGSIHCDP LPQKVIPMIG YVEIMEISAS VLGLLFLVGI
     FVCIRKRYVQ QKKKKPVCVQ DSNGYFQPSL AKSLKADNQD VNPIEMSSLV GPTNDLDHTP
     FRSLRPHSQI GSSGGGVSSA KTQGPVVCSV APNLPTRPPS SSDNDSIRKS HWDMDYEVYP
     ADPDYYGRPT VQEFPQFDIV EDTYSTSTME SRRNSRFGGF PFPLDRCDRR APLPPCYSNQ
     NLDDFLGPDG LPLPSSQCPN EYTAISYYPT QHTRSLDNVS GGYKRLSMRL SVAMPSYAEQ
     ASPPPAPNPA QPQTRPTGQN PRSYDGSSMV GSDYGSCEEV MF
//
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