ID   A0A3B4TRV0_SERDU        Unreviewed;       913 AA.
AC   A0A3B4TRV0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Metabotropic glutamate receptor 8-like {ECO:0000313|Ensembl:ENSSDUP00000008991.1};
GN   Name=GRM8 {ECO:0000313|Ensembl:ENSSDUP00000008991.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000008991.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000008991.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       {ECO:0000256|ARBA:ARBA00007242}.
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DR   AlphaFoldDB; A0A3B4TRV0; -.
DR   Ensembl; ENSSDUT00000009167.1; ENSSDUP00000008991.1; ENSSDUG00000006607.1.
DR   GeneTree; ENSGT01030000234648; -.
DR   OMA; MNQDISE; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR001786; GPCR_3_mGluR4.
DR   InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   PANTHER; PTHR24060:SF26; METABOTROPIC GLUTAMATE RECEPTOR 8; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01054; MTABOTROPC4R.
DR   PRINTS; PR00593; MTABOTROPICR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        596..616
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        636..656
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        662..681
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        702..729
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        760..781
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        793..815
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        835..857
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          596..870
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          882..913
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   913 AA;  101670 MW;  FDD5334298C9326B CRC64;
     MEAQWNPTSY PQSPSVVFLL VATSYAWLLP VASPQRIPTD PQAAPEYAHS IRLDGDIILG
     GLFPVHSRGD RGTPCGELKK EKGIHRLEAM MFAIDLINKD PELLPNITLG ARILDTCSRD
     TYALEQSLTF VQALIERDGS DVRCANGDPP IFTKPDKIVG VIGAAASSVS IMVANILRLF
     KIPQVSYAST APELSDNTRY DFFSRVVPPD SYQAQAMMDI VTAMEWNYVS TLASEGNYGE
     SGVEAFIQIS RETGGVCIAQ SLKIPREPRP GEFDKIIRRL LETSNARAII MFANEDDIRR
     ILDAAKRNNQ TGHFLWVGSD SWGSKISPVI GQERVAEGAI TILPKRASVD AFDRYFRSRS
     LSNNRRNVWF AEFWEENFNC KLGMHGKRPG SLKKCTGLEK VGRDSSYEQE GKVQFVMDAV
     YAMAHALHRM HRELCYGYPG LCPRMASNID GKELLSHIRA VSFNGSAGTP VVFNENGDAP
     GRYDIFQYQI TNRSTAEYRV IGSWTNKLHL KVEAMRWRTG DPSLPASVCS IPCRAGERKK
     VVKGVPCCWH CERCEGYHYQ ASEFTCELCP YEMRPDANRT GCVPIPIIKL EWHSPWAIVP
     VFISMLGIIA TSFVIVTFVR YNDTPIVRAS GREMSYVLLT GIFLCYAITF LMIATPDVGV
     CSFRRIFLGL GMCFSYAALL TKTNRIHRIF EQGKKSVTAP RFISPASQLV ITFSLISVQL
     LGVFVWFAVD PPHTVVDYGE QRTQDPTSAR GVLKCDISDL SLICSLGYSI LLMVTCTVYA
     IKTRGVPETF NEAKPIGFTM YTTCIIWLAF IPIFFGTSQS AERMYIQTTT LTISLSLSAS
     VSLGMLYMPK VYIILFHPEQ NVPKRKRSFK AIVTAATMSG KLTQKGGDRP NGEVKTELCE
     SMETNSATEL ELG
//