ID   A0A3B4TWM8_SERDU        Unreviewed;       715 AA.
AC   A0A3B4TWM8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Zinc transporter ZIP12 {ECO:0000256|ARBA:ARBA00040591};
DE   AltName: Full=Solute carrier family 39 member 12 {ECO:0000256|ARBA:ARBA00042541};
DE   AltName: Full=Zrt- and Irt-like protein 12 {ECO:0000256|ARBA:ARBA00042971};
GN   Name=SLC39A12 {ECO:0000313|Ensembl:ENSSDUP00000010447.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000010447.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000010447.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC         ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000256|ARBA:ARBA00006939}.
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DR   AlphaFoldDB; A0A3B4TWM8; -.
DR   STRING; 41447.ENSSDUP00000010447; -.
DR   Ensembl; ENSSDUT00000010642.1; ENSSDUP00000010447.1; ENSSDUG00000007638.1.
DR   GeneTree; ENSGT00940000157914; -.
DR   OMA; AQVCFSA; -.
DR   OrthoDB; 5488029at2759; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003689; ZIP.
DR   InterPro; IPR049406; ZIP4_12_EF-hand.
DR   InterPro; IPR041137; ZIP4_N.
DR   PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR   PANTHER; PTHR12191:SF4; ZINC TRANSPORTER ZIP12; 1.
DR   Pfam; PF21116; EF-hand_Zip; 1.
DR   Pfam; PF02535; Zip; 1.
DR   Pfam; PF18292; ZIP4_domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..45
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           46..715
FT                   /note="Zinc transporter ZIP12"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017263856"
FT   TRANSMEM        400..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        430..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        478..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        627..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        653..674
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        686..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          78..258
FT                   /note="Zinc transporter ZIP4 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18292"
FT   DOMAIN          266..381
FT                   /note="Zinc transporter ZIP4/12 EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF21116"
FT   REGION          301..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  78450 MW;  DE8F7C9896DE29C1 CRC64;
     MLLASPGSSR ESDVPGRNMH FRSSAPFLLL LLPLCLLGRV LEVKGQEWGY LQEALKALDL
     PLGMEDQPQL QKNKTDVLIT TLLQVMHCAD RTGTSQDICD KCLTPDVALS VLEDDGKAYL
     TEEEYQRIST VLLYYIINLR DLCMSSAASH SSLSSSSSSS SSSSSSSGNY QFYLLALTNL
     HPGEDNRFLS LSETESILQL INQHYDPSNQ ETSSELQCID ATQILEDADI KENPGAGESS
     VPKVAAAIIS HILQGHCFRR RNLPSPAFFT DYIFQSLNRT SNLQMMDLEE LLHQLGVGRE
     GASVPHNRKR RSITGSAQKA AGHQVDGCNH ETGGVSRDWA QVCFSANQLV DIFALDPHLP
     ISREHFRQIC PAIIQQLLGN ACESAEQKTR GSLPTALEKY GYSTAAVLLI TVGSMFGICL
     IFFNSCQETY TLILQLFVGL AVGTLSGDAL LHLIPQILGL HDDTHSHVDE HYTERKDYLW
     KILGMIGGIY GFFLIERMFS VLVPSHGHGP SSDLPLEVSC NGQRGKSIST IQLGPVDDLE
     CAEISPEHAD TRSPSHRRQG VPLLAVMVIV GDSLHNFADG LVVGAAFSYS AETGMATTVA
     ILCHEIPHEM GDFAVLLSSG LSVKTAVLMN FLSALTAFMG LYIGLFVSSE TEVQQWIFTV
     TAGIFLYLSL VEMLPEMSRV KTDRPCLMFL LQNLGLLMGW ACLLLLALFE HELKF
//