ID A0A3B4TWR3_SERDU Unreviewed; 2174 AA.
AC A0A3B4TWR3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Unconventional myosin-VIIa-like {ECO:0000313|Ensembl:ENSSDUP00000010433.1};
GN Name=MYO7A {ECO:0000313|Ensembl:ENSSDUP00000010433.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000010433.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000010433.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 41447.ENSSDUP00000010433; -.
DR Ensembl; ENSSDUT00000010629.1; ENSSDUP00000010433.1; ENSSDUG00000007550.1.
DR GeneTree; ENSGT00940000155350; -.
DR OMA; PKCQMVI; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF34; MYOSIN VIIA; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 65..741
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1017..1250
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1255..1564
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1562..1631
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1706..1854
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1860..2163
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 618..640
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 883..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..935
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 158..165
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2174 AA; 250794 MW; AF0B977BB212F651 CRC64;
LCFMTQGDYV WLDLKTGREF DVPVGAVVKL CDSGQIHVLD DEGREHWISP QNATNIKPMH
PTSIHGVEDM IRLGDLNEAG ILRNLLIRYN ECVIYTYTGS ILVAVNPYQL LPIYTPDQIR
LYTNKKIGEM PPHIFAIADN CYFNMQRNNK DQCCIISGES GAGKTESTKL ILQFLAAISG
QHSWIEQQVL EATPILEAFG NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS
RVCRQAPDER NYHVFYCVLK GMPPEMKAKL GLGLATDYAY LTMGNCTECD GRDDLNDYSS
ILSAMKVLMF TETENWEISK LLAAILHMGN LRFEARTYDN LDACVVVRSP DLVTAASLME
VEPKDVMVCL TTRTLITRGE SVVTPLSVGQ GLDVRDAFVK GIYGRLFVWI VDKINAAIFR
PPSCESNIIR RSIGLLDIFG FENFIVNSFE QLCINFANEN LQQFFVRHVF KLEQEEYNLE
DISWQHIEFT DNQDALDMIA NKPMNIISLI DEESKFPKGT DATMLYKLNS QHKLNSNYIP
PKNCYETQFG IQHFAGVVHY ETRGFLEKNR DSLHTDIIQL VHSSKNKFIK QIFQADVAMG
AETRKRSPTL SSQFKRSLEM LMRTLSVCQP FFVRCVKPNE FKRPMLFDRE LCIRQLRYSG
MMETIRIRRA GYPIRYTFAE FVDRYRVLMP GVKPAHKQED LRGTCQQIVQ ARLGKHDDWQ
IGKTKIFLKD HHDMQLEIER DKAITDKVIL IQKAVRGLKE RTNFLRVKRA VIFIQKVWRG
YRCRKDYQIS GFLRLQAVYR SRKHYRSYRM TRLRVTLIQA RCRGFLIRQT FWRRLRAVLT
IQAYTRGMIA RRLCQRLRAE LQRRLEAERQ RLAEEEQLRN QMTARRAKAE AERKHQQRLV
QLAQQQEERE REEREEARRK KEMLEQMERE KEQPVDHSDM VDRVFGFLGN SGPLPNQDGQ
APAGFEDLEN TPRGEEAEEE VLNEAPPLPD EEEEDLSEYK FSKFAATYFQ GVSTHTYIRR
PLKQPLLFHE DEGDQLAALA VWITVLRFMG DLPEPKCQMV INDGSEKIPV MTKIYETLGK
RTYKRELQEL QVEGEHAEGG RNSVRHKLVS LTLKRKSKIT EEVTRRLTDG DYALQGNSML
EDRPTSNLEK LHFIIGNGIL RPALRDEIYC QICKQLTQNP SKSSHARGWI LLSLCVGCFA
PSEKFVKYLR TFLINGPPGY APYCEERLRR TFVNRTRTQP PSWLELQATK SKKPIMLPVT
FMDGTTKTLL ADSATTASEL CNALADKINL RDRFGFSLYI ALFDKVSSLG SGSDHVMDAV
SQCEQYAKEQ GAQERNAPWR LFFRKEIFSP WHNPAEDYAA TNLIYQQIVR GVKFGEYRCE
REEDLAELAS QQYYVDYGSE ILQERLLSLI PSYIPDREIT STKTAEKWVQ LIISAHKKGL
YTKRRMNTQR VKEDVVDFAR LKWPLLFSRF YEAFKFSGPS LPKNDVIVAV NWTGVYFVDE
QEQVLLELSF PEITAVSSSR GGKLQGQSFT LATMKGDEYT FTSNNAEDIR DLVVSFLEGL
RKRSKYVVGL LDCPNPVGAD SPFLSFSKGD LIILDEHDGE HVMNSGWAHG INDRTKQRGD
FPADCVYVLP TVTRPQYDIV ALVTMTPDQR RESIGLSQMN LSGHEDKTKA YTLELFSYDY
FRAPPKSTLS RVMISKARGK ERLWSCTREP LKQPLLKKVL AHEELSQEAC LSVPVMKYMG
DYPSKRARSV NELTDQIFEG ALKAEPLKDE IFCQVLKQLT DNPIKYSEEK GWELLWLCTG
LFPPSNILLP HVQKFLQAKK HYPLAPDCMQ RLQKALRNGS RKYPPHLVEV EAIQHKTTQI
FHKVYFPDDS DEVFEVESST KAKDFCHNIS GRLMLKSSEG FSLFVKITDK VISVPDGDFF
FDFVRHLTDW IKKARHVKDG VVPSLTYQVF FMKKLWTNTM PGKDSMADSI FHYYQELPKY
LRGYHKCSRE EVHQLAALIY RVKFDEDKSH FQNISKILRE LVPQDQVRHL SPDDWKRSVL
SLYNKHAGKT REEAKLSLLK IIYKWPTFGS AFFEVKQTTD PNYPETLLIA INKHGVSLID
PKSKDILTTH PFTKISNWSS GNTYFHITIG NLVRGSKLLC ETSLGYKMDD LLTSYISQML
TTMTKQRSTR GNSK
//
