ID   A0A3B4TWU0_SERDU        Unreviewed;       167 AA.
AC   A0A3B4TWU0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=von Hippel-Lindau tumor suppressor {ECO:0000313|Ensembl:ENSSDUP00000010512.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000010512.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000010512.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VHL family. {ECO:0000256|ARBA:ARBA00010057}.
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DR   AlphaFoldDB; A0A3B4TWU0; -.
DR   STRING; 41447.ENSSDUP00000010512; -.
DR   Ensembl; ENSSDUT00000010709.1; ENSSDUP00000010512.1; ENSSDUG00000007705.1.
DR   GeneTree; ENSGT00390000014353; -.
DR   OMA; VGHPWLF; -.
DR   OrthoDB; 2951928at2759; -.
DR   Proteomes; UP000261420; Unplaced.
DR   CDD; cd05468; pVHL; 1.
DR   Gene3D; 1.10.750.10; von Hippel-Lindau disease tumour suppressor, alpha domain; 1.
DR   Gene3D; 2.60.40.780; von Hippel-Lindau disease tumour suppressor, beta domain; 1.
DR   InterPro; IPR024048; VHL_alpha_dom.
DR   InterPro; IPR037139; VHL_alpha_dom_sf.
DR   InterPro; IPR024053; VHL_beta_dom.
DR   InterPro; IPR037140; VHL_beta_dom_sf.
DR   InterPro; IPR036208; VHL_sf.
DR   InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR   Pfam; PF01847; VHL; 1.
DR   Pfam; PF17211; VHL_C; 1.
DR   SUPFAM; SSF49468; VHL; 1.
PE   3: Inferred from homology;
FT   DOMAIN          12..93
FT                   /note="von Hippel-Lindau disease tumour suppressor beta"
FT                   /evidence="ECO:0000259|Pfam:PF01847"
FT   DOMAIN          105..153
FT                   /note="von Hippel-Lindau disease tumour suppressor alpha"
FT                   /evidence="ECO:0000259|Pfam:PF17211"
SQ   SEQUENCE   167 AA;  19604 MW;  B2E30555352CF1C7 CRC64;
     MPQEGEQSLP LVRSLNTQIQ INAVFCNRTP RVVRPLWIDY RGEPQPYHDI QPGTGRRMNT
     FVGHPWMFRD AETDEPLKVN SKELFLPKPT EGGNATFANI TLPVYSLKDR ALQVIRRLVR
     PEDYRRLEIA RCLHEELEDQ PSVLKDLHRM NQRVEQHLLE RIQGQEE
//