ID A0A3B4TX50_SERDU Unreviewed; 515 AA.
AC A0A3B4TX50;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000010285.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000010285.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR AlphaFoldDB; A0A3B4TX50; -.
DR Ensembl; ENSSDUT00000010478.1; ENSSDUP00000010285.1; ENSSDUG00000007470.1.
DR GeneTree; ENSGT01050000244891; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF6; IMPORTIN SUBUNIT ALPHA-4; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..58
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 108..152
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 151..178
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 278..316
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 56959 MW; 207A8C66E698224A CRC64;
MAENAGLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN VPLEESLEDS
DVDSDFKGVS VGNATSDNAV IQLSAVQAAR KLLSSDRNPP IDDLIKSGIL PILVKCLERD
DNPSLQFEAA WALTNIASGT SAQTQAVVKS NAVPLFLRLL HSPHQNVCEQ AVWALGNIIG
DGPQCRDYVI SLGVVKPLLS FINPSIPITF LRNVTWVIVN LCRNKDPPPP METVQEILPA
LCVLIYHTDI NILVDTVWAL SYLTDGGNEQ IQMVIDSGVV PFLVPLLSHQ EVKVQTAALR
AVGNIVTGTD EQTQVVLNCD VLSHFPNLLT HPKEKINKEA VWFLSNITAG NQQQVQAVID
AGLIPMIIHQ LAKGDFGTQK EAAWAISNLT ISGRKDQVEF LVEQNVIPPF CSLLSVKDSQ
VVQVVLDGLK NILIMAGDEA STIAEIIEEC GGLEKIENLQ QHENEDIYKL AFEIIDQYFS
GDDIDEDPSL IPETTQGGTF NFDPASNMQT KEFNF
//
