ID A0A3B4U3Z0_SERDU Unreviewed; 1677 AA.
AC A0A3B4U3Z0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 1-like {ECO:0000313|Ensembl:ENSSDUP00000012903.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000012903.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000012903.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 41447.ENSSDUP00000012903; -.
DR Ensembl; ENSSDUT00000013136.1; ENSSDUP00000012903.1; ENSSDUG00000009352.1.
DR GeneTree; ENSGT00940000155024; -.
DR OMA; YAIAYIC; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF13; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 862..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 959..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1018
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1081..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1137..1156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..370
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 869..1115
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1211..1266
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 442..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1658..1677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1677 AA; 190017 MW; 16766A972FB1AC55 CRC64;
MSTNFFFLSS IFSLQAQKAW IERTFLKREC IHIFPSKDPT RCACGQLTTQ HVAIPPGANS
VEETNQLVQI DTPKDKWTVI KYTRTYPTDA FGIIEFQGGG FVNKAMYIRV SYDTKPDNLL
HLMVKDWQLE LPTLLISVHG GLQNFDLQPK LKQVFGKGLI KAAVTTGAWI FTGGVNTGVI
RHVGDALKDH SSKSRGKVCA IGIAPWGILE NKEDLIGKDV TRPYQTMANP LSKLAVLNNS
HSHFILTDNG TCGKYGSEVK LRRLLEKHIS LQKINTRLGQ GVPLVCLIVE GGPNVISIAL
ESLRDDPPIP VVVCDGSGRA SDIISFAHKF SEDGGLVNDD VRDQLLVTIQ KTFNYTKSQS
QQILLMVMEC MKKRELITVF RMGSEGQQDI EMAILTALLK GTNASAADQL SLALAWNRVD
IARNHIFVYG HNLPPAGAIA STTTSAAPMQ EKQKSPASAP RNKTRAKKGK GKGKAKPEPP
EETDPRKLEL IRWVNSLEQA MMDALVLDRV DFVKLLLENG VNIHHFLTIP RLEELYNTKL
GPPNTLHAVV RDVKKGNLPP DYQITLIDIG LVLEYLMGGA YRSNYTRKAF RNLYNNLYGL
KRPKALKLLG MEDDEPRTKG KKKPKKKKEE EVEIDVDDPE VCRFKYPFHE LMLWGVLMKR
QKMALFLWQR GEEAMAKALV ACKLYKAMAH ECSESELVDD ISQDLENNSK EFGQLAYELL
DQSYKHDEQV AMKLLTYELV NWSNSTCLKL AVAAKQRDFI AHTCSQMLLT DMWMGCLRIG
KNPGLKVILG IICPPLILLL DFRLGDDHAP GGKEERKDKD DDDPNNDTTS RKGDEEEGST
KVHKIPIGKR FFEFYDAPFT KFWFNTICYL GYLMLYNYII LVKMERWPSL QEWTVIAYIL
TLGTEKVRQI LMSEPGKLKQ KISVWLEEYW NITDLVAIST FLLGLMLRLQ HEPYMGYGRV
IYCIDIIFWY IRVLDIFGVN KYLGPYVMMI GKMMIDMMYF VVIMLVVLMS FGVARQAILH
PDEEPTWRLA RNIFYMPYWM IYGEVFADSI DLYAMEINPP CGEHLYDEDG KKLPPCIPGA
WLTPAIMACY LLVANILLVN LLIAVFNNTF FEVKSISNQV WKFQRYQLIM TFHDRPILPP
PLIIFSHLYI LFNRLFRRCA RKKQEGELDE KDRGLKLRLN PEELKNLYEF EEQCVEEYFR
EKEDEQQSSS DERIKVTSER VENMSMRLEE VNERENTMKA SLQTVDLRLA QLEEIHGRMA
VALEKLAGVD RLELTRTYSR NSSVCDPSSL LRQGSINSAD GYSLYRFHMD MEEYASKQKD
TDETTKTGLE RQRSICTLNT KDGGQTLEVA CLERSRPSSC VDILISPCEQ KPASAASSQE
TISNIKQGST LLLDRLTDKN RLKPSSPPKR TKSLRYYPVE DQLTCALTKR RAMSTIIVSP
PDEPEEAAEP TKKAQMLLGT SSSPKRTESL RYVPTETQSQ TSPITKKRAM SGIVYNPAEA
GDDVLQTADY RSLVEQVTKT PNQWPASLEY QVHPSTFGHI PKVSTVRALA QQFQSSTGPA
ELKNEENQLD QIPTENKATL PGTEPVEDGA KMKAKRNLSD TTEYLTVADE RCLPSHRSQS
WNASERKAKC LMVSKEPRAS SSERNLAEVC RVAAVGGEDV GKKIEAEKGE DDAQEKK
//
