ID A0A3B4U4W1_SERDU Unreviewed; 690 AA.
AC A0A3B4U4W1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000013649.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000013649.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B4U4W1; -.
DR STRING; 41447.ENSSDUP00000013649; -.
DR Ensembl; ENSSDUT00000013895.1; ENSSDUP00000013649.1; ENSSDUG00000009921.1.
DR GeneTree; ENSGT00940000167177; -.
DR OMA; ICLAGCT; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF320; DELTA-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..690
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017272872"
FT TRANSMEM 531..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..210
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 277..315
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 317..353
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 355..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..469
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 471..511
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 168..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 181..193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 201..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 305..314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 343..352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 364..381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 383..392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 459..468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 501..510
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 690 AA; 76339 MW; EC978E65E6260A9C CRC64;
MAAWFTFTIA FSTTLITQVF GSGVFELDLH EFKNHKGLLA NGNACKPNCR TYFTICLKNY
QAVVSPGDCI FGSTMTPVLG TNSFSAKDSG TLPRPIQIPF NFGWPGSFSL IIEAWHSPYG
NLPVDTNNPD FLISFFAIQR QMGVGTDWSQ DTQMAKQTEL RYSYRFICNE SYYGESCSKK
CTPRDDRFGH YTCTRDGQLS CLPGWKGKYC EEPICLEGCS ERNGNCSRPG ECVCRDGWQG
TFCDECKKYP ACKHGTCQLP WQCNCQEGWG GLLCDQDLNF CTHHHPCVNG ATCMNTGQGS
YTCTCLPGFT GVTCELEMQE CDSNPCRNGG LCTNLESGYM CRCPQGFEGS HCEHSLLTCA
DSPCFHSGKC WEKDNGRSYM CECPRGYTGL NCEKRVDKCT SLPCANGGLC LIHGGIRACS
CRAGFTGQRC EININECAGN PCLNGGTCRD RINDYTCACP SGYSGRNCDR VLDECSLHPC
LNGGICTGGD GPGKPPATCI CPSGFTGHRC EFFAAVTSPV TNGEIQDGFQ WAAVSLAVGL
VALLVLLCMV GLALRHIHRQ AQRERGDTET MNNLSNFQRD NLIPASQLKN TNQKIGLEVD
CDSEKSNFIH KNYHLDSYNS KSKEFKDEKS QEDKSLIYEK CLEDKMPLSR MYSEKPECRI
STICSSRDSM YQSVFVIAEE RRECVIATEV
//
