ID   A0A3B4U7K7_SERDU        Unreviewed;      1059 AA.
AC   A0A3B4U7K7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Insulin receptor substrate 2-like {ECO:0000313|Ensembl:ENSSDUP00000014183.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000014183.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000014183.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4U7K7; -.
DR   STRING; 41447.ENSSDUP00000014183; -.
DR   Ensembl; ENSSDUT00000014453.1; ENSSDUP00000014183.1; ENSSDUG00000010333.1.
DR   GeneTree; ENSGT00940000161407; -.
DR   OMA; PCGYMLM; -.
DR   OrthoDB; 4212441at2759; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR   CDD; cd01257; PH_IRS; 1.
DR   CDD; cd01204; PTB_IRS; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR039011; IRS.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR   PANTHER; PTHR10614:SF7; INSULIN RECEPTOR SUBSTRATE 2; 1.
DR   Pfam; PF02174; IRS; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00628; INSULINRSI.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS51064; IRS_PTB; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          18..119
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          151..255
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
FT   REGION          257..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          631..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          717..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          792..824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          970..997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..808
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        974..997
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1059 AA;  113491 MW;  48342E6606BDA71F CRC64;
     MASPPATGGH LLSNGTNGVK KCGYLRKQKH GHRRFFVLRE PTERCPARLE YYESEKKWRN
     KSAAKRVITL DSCLCVNKRA DAKHKHLIAL YTKDEYFAVA ADNEQEQESW FGVLTDLIAE
     GKVYDSPAST SSLVGFEEAS YGLITPAAAA YKEVWQVNLK SKGLGQIKNL TGVYRLCLSS
     RTISFVKLNS ETAAVSLQLM NIRRCGHSDS FFFIEVGRSA VTGPGEFWMQ AEDSVVAQNI
     HETILEAMKA MKELSEFRPR SKSQSASTNP ISVPTRRNLN NLPPSQTGLV RRSRTDSMAA
     TSPGRKFTSC RIRTASEGDG SVTRPVSMSI SVNGSPTSPS CGNHLSRSHT LSSGRTCRML
     ESSSNLHHSR SMPVSNSPPA ASSPISMSPR GGAGISTPDK ARRPFSCSAS ISGSLSDTGF
     MLCDDYSSSP GEPKFLPLTR SDTPDSLSST PPSRDISDPC GYMIMEGANG GRVLAGGDLA
     FDKAYRKRTH SLTTPRQQRV VAPLSSASLD EYTLMRMAHG QNSHSASPKV CYPEDYGDIE
     IGSSRSSSSN LGDDGYMPMT PGVAPQSGKG DNYVPMSPMC VSAPKQIVNP RVHPQAGAGG
     GGGGYKTNSP CSSSLEDNGY MRMWCGSKSS MESPDRHGEY MNMSPGNPPP LQTPPDYYLG
     LLAGEPAPVR SAYQGGSLTL PAKLQASKNE DGCQYVLMSP QSVRQRAGES DYYSVMQPSA
     AQTSPLSPSV PSPVRHGRVE NLAYRGRLGR PNRLSLDTLR TLPSMNEHPL PGEPRSPGEY
     INIDFSCTRF SPPSIVSTES QSSSLGSGGG GGGGGGGPGR SSLTDYINLE LASHSPKEVN
     TPSARPVLSM CPCSEEDGVY QTGSQGLGSE MKNDYTEMTF GMTSSPPQLV PQNTASSQRR
     LSLEDQGVPE SIGVFLLGAT SSPTVDPDCS AKVIRANPQG RRRHSSETFS STATVTPVFP
     SFARGDAVKR HSSVENISSR SSEGSDEEYG SPVNRQSSAG YPNGLNYIAL NLLDNRDVEK
     CEDLVGFKPT SSCKGGINGL HSTPYVCLGF KEAATTAKD
//