ID   A0A3B4U8K4_SERDU        Unreviewed;      1045 AA.
AC   A0A3B4U8K4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Signal-induced proliferation-associated 1 {ECO:0000313|Ensembl:ENSSDUP00000014984.1};
GN   Name=SIPA1 {ECO:0000313|Ensembl:ENSSDUP00000014984.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000014984.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000014984.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4U8K4; -.
DR   STRING; 41447.ENSSDUP00000014984; -.
DR   Ensembl; ENSSDUT00000015268.1; ENSSDUP00000014984.1; ENSSDUG00000010925.1.
DR   GeneTree; ENSGT00940000160644; -.
DR   OMA; PYDNIGG; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF14; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          469..684
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          20..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          927..1045
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        939..957
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        994..1037
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  116021 MW;  2537FDF99AE43756 CRC64;
     MQSDDLFIRK FRRQNVRPPI ATVNFDPKPE AGVVEWPPRR DGDGADGDSL TPSRVGLNLR
     SVGRGHIMQR SNSDVTLGDL DSSGKAGGKA ARAVGEKVGV GAQGDSGVLL HREYGSLSSL
     ERQTQAQEPS TDDQGPLSPN ALRFKDPFLL LGLQGNPPEP DGFFRGLSVS TGDSPKPAKP
     PKPEGLSKKT KPGPPQIPQP GPYDNLGGGA WVRNFAHYDV QSILFDLTEA ATNRDSIGRK
     KNITSGASAA SQLRPLSQAA PSSPAQGGGG NGVNADDPEQ SLLLDEGDGN DNELLLSCPH
     FRNETGGEEQ VGLGRSQGRR GLWSSLRTPN DAVSVLEEPR ESHVQQQGKS NYFIEHADLG
     AHYYRKYFYM KHQNFFGMDD RLGPVAISFR REEKEGSSGA QYNYRIIFRT TEQMKTLRGS
     ILEESVPSAA RHTTPRGLSP KRLLEFIMPE LNLHCLRLAS NSPKVRDTLL KLDEQGLNFQ
     RKVGVMYCRA GQSSEEDMYN NESSGPAFEE FLDLLGERVR LKGWEKYRAQ LDNKDSTGTH
     SLYTRYQDYE IMFHVSTMLP YTANNTQQLL RKRHIGNDIV TIVFQEPGAL PFTPKSIRSH
     FQHVFIIVQV HEPCTDNTYY VAVTRSKDMP LFGPLFPKGA RFPRTPAFRD FLLAKAVNAE
     NAAEKSEKFR SMATRTRQEY LKDLAENYVT TTPIDSSTKF PLLSLGGKRK DKLKGTKGAE
     LHSAGALVWA VMVYSRDEGE AGELKLPCLL GVSAESVVLI ERYTRRVVFN CSCRDVIGWK
     AVTETKEGGP CLDIFYERGE SVSICVMESQ VEDIREVVQR LELVTRGCEA LEVTPLRDGV
     GQPGFLMNEE GFVTELQRFC YAESGGLQLW ARVVRLCGHS LVHLSPEERT RLLRTAHKIH
     ITVIPPDENG KPRSFSELYQ KAIKDAECKP GEDQSGEAWV LDEREEEEED EEEEAKEDEL
     KAGGVSEADI MEVQMEAEEG EEQSCDKGQS ERSHESLLTT PSLPLLRATS LQDQPANQSP
     EGSASQLTRS YSLERQPSYR DTCDG
//