ID A0A3B4UB07_SERDU Unreviewed; 1838 AA.
AC A0A3B4UB07;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Down syndrome cell adhesion molecule homolog {ECO:0000313|Ensembl:ENSSDUP00000015562.1};
GN Name=DSCAM {ECO:0000313|Ensembl:ENSSDUP00000015562.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000015562.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000015562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000256|ARBA:ARBA00034103}.
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DR STRING; 41447.ENSSDUP00000015562; -.
DR Ensembl; ENSSDUT00000015849.1; ENSSDUP00000015562.1; ENSSDUG00000011324.1.
DR GeneTree; ENSGT00940000154678; -.
DR OMA; DPTREWY; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048484; P:enteric nervous system development; IEA:Ensembl.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05734; Ig_DSCAM; 1.
DR CDD; cd05735; Ig_DSCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF51; DOWN SYNDROME CELL ADHESION MOLECULE; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 6.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 8.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 7.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1431..1452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..151
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 155..243
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 249..342
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 345..431
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 437..526
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 531..626
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 630..726
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 728..825
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 830..930
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 935..1031
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1035..1128
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1215..1309
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1314..1405
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 816..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1540..1638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1761..1838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1574..1638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1810..1838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1838 AA; 203916 MW; 0D45C91773B3F4AD CRC64;
MCFHLLFLSA SGQRYLITST GALYILDVLP EDGLNNYRCT TRHRYTGETR QSNSARLIVS
DPTNAEPGIL DGFDHREVMI NHRVELPCKA SGYPTPKYRW LKDNSPLEPD SRFRQTITGL
LIESTQPSDS GTYVCEVWNS YGNAEVMGRL YVKQPLKAVV SPRKVKGSVG SKVSLSCSVS
GSDEYELSWY RNGEIIYPGN NVRFTGLNRE NLIMEGMSKS DGGAYQCFAR KGKMSAQDFV
QVILEDGTPK ILSSFSEKVV NPNEPVFLVC NVKGTPPPRC TWSLDDDPVI KDSHHHLGHY
ETHEGHVVSQ LNVTHTQVQD GGVYRCTCSN SAGVVYHQAR INVRGRASIR PMKNITAIAG
RDAFVHCRVI GYPYYSIKWY KNSALLPFNH RQRAFENNGT LKLTNVQQVD AGEYNCKVMV
QPNKMDSQSV HVRVRVPPYI QPFEFQRFTI GQRVFIPCVV MSGDRPLDIT WQKDGRPIPA
SLGVTVDNID FTSSLRISNL TPDHNGNYTC IARNEAAAVE HQSQLIVRVP PQFVVQPEDQ
DGIYGKTVTL NCSAEGYPPP TIVWEHSKGA GVPQFQPILL NSGSRIQLLS NGSLLIKHVL
EDDSGFYLCK VSNDVGADVS KSMYLTVKIP AMITSYPNTT LATQGEEKRM SCIAHGEKPI
MVRWEKEERI INPETSRYVV TVKEVADEVI STLVIMPTVR EDSGFFSCHA INSFGEDRGI
IQLTVQEPPD PPEVEIREVK DRTIALRWTM GFDGNSPITG YDIECKNKSA SWLSAQVTKD
VSPQLNQATI IDLHPSSTYN IRMVAKNIIG NSNPSNELTI TTDEAAPDGP PQDVTLEPTS
PQSIKVSWKP PQKHLQNGVI RGYQVGYREY SPGGSHQFTI ISVDTTGDTT ESIVLDNLKK
FTQYSVVVQA ANRAGTGPSS QQVVTKTLED VPSRPPENVL AVAKSPEVIS LSWMPLPREA
LNGNLQGYRV IYWANLPDGE LGEIRNVTTN QPSLELDGLE KYTNYSIQVL AFTNAGDGVR
SEQIYVRTKE DVPGPPAGVK AAASSSSVVF VSWLPPLKLN GIIRKYIVFC SNLHPMVMSE
FEASPDAYFY RIPNLARNRQ YSIWVVAVTA AGHGNNSEKI TVEPLAKDRI SHFQGYCENS
FCFFTCRNVS TSFLFFSSTN GTPTPVLVDG RRSVHGNGSF IIRTVKAEDS GNYSCVASNN
WGSDEITLNL QVQVPPDQPR LTVTKTTTTS ITLSWIPGDN GGSSIRGYIL QYSEDNSEQW
GSFPISPSER SYRLENLKCG TWYKFTLTAQ NAVGPGRISE IIEAKTHGKE PQFAKEHELF
TSINSTRARL NLVGWNNGGC PITSFILEYR AVDSATWTTA QRTSLTKSYI LYDLQEATWY
ELQMKVTNSA GSAEKRITFA TLNADGSTIP PLLKTGDPIS DNMSGSGGLK MVVTITSILV
VAVLVFIMLM VLKRRRREQR LKRLRGDKNT RTPDTVNKQQ QTLRMHIDIP RAQLLIEERD
TMETIDDRST VLLTDNDFGE TNKQKSSTVT HTVHYQSLSQ ATGPLVDVSD ARPGTNPTAR
RTAKAGPAAA RSRYASQWTL NRPHPTSSSH TLTTDWRLPT PRATGSVDKE SDSYSVSPSQ
DTDRARSSMV STESASSTYE ELARAYEHAK MEEQLRHAKF TITECFISDT SSEQMTAGTN
DYTDSLTSST PSESGICRFT ASPPKPQDVS RVMNMAVPKA HRPGGELVHL PPYLRMDFLL
NRGVPLAARG GAMGQTCLEP QRSRTLKRPP PMEPTPMEVP SPREVQQWQP GTASTLPHRD
VRERGEAAKL STSQESLLDS RGHLKQSNNP YAKSYTLV
//
