ID A0A3B4UB15_SERDU Unreviewed; 99 AA.
AC A0A3B4UB15;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 9 {ECO:0000256|ARBA:ARBA00020636, ECO:0000256|RuleBase:RU364145};
DE AltName: Full=Mediator complex subunit 9 {ECO:0000256|ARBA:ARBA00031260, ECO:0000256|RuleBase:RU364145};
GN Name=MED9 {ECO:0000256|RuleBase:RU364145,
GN ECO:0000313|Ensembl:ENSSDUP00000015849.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000015849.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000015849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687,
CC ECO:0000256|RuleBase:RU364145}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364145}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364145}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC {ECO:0000256|ARBA:ARBA00008089, ECO:0000256|RuleBase:RU364145}.
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DR AlphaFoldDB; A0A3B4UB15; -.
DR STRING; 41447.ENSSDUP00000015849; -.
DR Ensembl; ENSSDUT00000016137.1; ENSSDUP00000015849.1; ENSSDUG00000011562.1.
DR GeneTree; ENSGT00390000017379; -.
DR OMA; VEKDPHD; -.
DR OrthoDB; 4616030at2759; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR011425; Med9.
DR InterPro; IPR039242; MED9_metazoa.
DR PANTHER; PTHR20844:SF0; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9; 1.
DR PANTHER; PTHR20844; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9; 1.
DR Pfam; PF07544; Med9; 1.
DR SUPFAM; SSF140718; Mediator hinge subcomplex-like; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364145};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364145};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364145};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364145}.
FT COILED 32..90
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 99 AA; 11264 MW; B81B58F4750B7F11 CRC64;
MAVAQPKLEK ESEDCSLLPL VHDIIKCMDK DSQDVHQELA KLKAKIQEAR EQISNMPGID
SSPVEQQQQL ATLREQVRTK NQLLQKYKSL CMFDVPKAS
//
