ID   A0A3B4UB57_SERDU        Unreviewed;       860 AA.
AC   A0A3B4UB57;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=G-protein coupled receptor family C group 6 member A {ECO:0000256|ARBA:ARBA00039774};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000015901.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000015901.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B4UB57; -.
DR   Ensembl; ENSSDUT00000016189.1; ENSSDUP00000015901.1; ENSSDUG00000011492.1.
DR   GeneTree; ENSGT00940000158416; -.
DR   OMA; HESVQEH; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF5; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..860
FT                   /note="G-protein coupled receptor family C group 6 member
FT                   A"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017349556"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        548..571
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        583..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        624..644
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        669..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        703..725
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        737..760
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          513..775
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   860 AA;  96578 MW;  354D1710C8A48C25 CRC64;
     MRHFLSFYIF SLVLLNHVFR ATGFDSATAP GDIIIGGLFP IHESVDVTTR EDGTESRICN
     RFNIARLVQS LIMVQAVEDV NTRHELGNLT LGYYILDSCN DVTTALMNTQ SFMKRNDGTE
     QTQPPVLAVV GDYYSEISIA VTRHLHLEYI PQISYGATSG VLSDKARFPS FMRTVPEDDH
     QAQAIVEILQ NHNWTWVGVV TTDSDYGRYI VEHLQKHAAN KNICFAFTSI IPDDLGHKRL
     NKSISAAVKR ITENKNVSVI VSFARPHHMM YIFEHLLKVP EGRGKVWVAS DIWSETADVV
     KNHNLSDIGT IFGTTLKSGN STRLKQYLSN LDVNPHSPRG ENPNATATEV LMKKIYPYAV
     FSVELAVRAI AQAVADLCVN RDCKTNERLD PVELREALRK ATFLMHGKNY SFDSKGDLNS
     GYDIILWRQT SPTFVDVHYV VAHYSIENEN LNILGDVVSR CSESCRPGQM KQSIPGMPVC
     CYECQPCPEN YFSNTSSMYQ TKKTVFFYWT DVYHHVLQAF TALGALLTIV VGIIFLARWN
     TPVVRASVGP ICIILLLSLL STFVSVILFG GEPNNKQCQA RQVLFGLSFT MCVSCIMVKS
     FKIILAFEFD PSVKRVLKKL YKPYIIIAVC MAGQVLICAL WLSLGPPVRE WKELSKKDER
     LLICSEKSFS AFGAMLGYIG VLALICFGVA FKGRKLPESY NDAKFITFAM LIYFICWIIF
     GPVYVNVIGR YHPAVEMVVI LISAYGILFC QFFVKCYIIL FKQNANTEAA FRQDVRNYSL
     SQIKDEAGNW VLTPSSSGGI QNTAVDVESQ ISSSDQKIDQ IPSMSTHPSS FFLSALNPRL
     ITLQSNSNKR QLRRYLSSPA
//