ID A0A3B4UHW8_SERDU Unreviewed; 672 AA.
AC A0A3B4UHW8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma-like {ECO:0000313|Ensembl:ENSSDUP00000017992.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000017992.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000017992.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR AlphaFoldDB; A0A3B4UHW8; -.
DR Ensembl; ENSSDUT00000018320.1; ENSSDUP00000017992.1; ENSSDUG00000013068.1.
DR GeneTree; ENSGT00940000157050; -.
DR OMA; QSDMGFL; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12926; iSH2_PIK3R2; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..80
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 274..369
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 563..658
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 381..415
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 453..501
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 672 AA; 77270 MW; 40FF16E80AE2F474 CRC64;
MAAEGFQYRA LYAFTKDQEE DLDLQPGDLL TVSKASLLSM ENYQEGCEEQ PEHLGWLLGY
NERTKQRGDF PGTYVEYVGP VKMVLPSSQP RSQRPLPAAP RSESSQAVSV LDLSEQFTPP
ETAPPALVNL IQAIERRGIS MSTSHRIYGA VAGSHDREVS QVLESSTTVP LHHRLTLQYL
LTHLTKVTQV QASNGLDTHT LGKIFGPLLI RTGASTPWLS VDEKFPALVV ERLLIERITE
QDLTPPVLPA KPVKSKMAPS AMTDTSSLLN DAEWYWGEIS REEVNEKLRD TPDGTFLVRD
ASSKLEGEYT LTLRKGGNNK LIKIYHRDGR YGFSEPLTFL SVVELINHYR HESLAQYNAK
LDTKLLYPIS KYQQLVKENS IEEVGEQLKV YHEQYQEKSR EYDSLYEEYT RTSQELQMKR
TAIEAFNETI KIFEEQCETQ ERYSRESLER FQREGNEKEI QKIQSNSERL KSRVKEIHDS
KRKLEQDLRQ QVSDNREIDK KMNSLKPDLM QLRKIRDQYL IWLTQKGTRQ KKINEWLGIK
NDADDSYSLE EDEGSPHHDE CTWYVGDIKR TQAEEMLRGK CDGTFLIRES QSQKGSYACS
VVVEGDTKHC VIYKTVTGYG FAEPYNLYSS LKDLVLHYKN VSLVQHNDQL NVNLAYPVLA
RSQNQNQNQH PR
//
