ID A0A3B4UJ71_SERDU Unreviewed; 771 AA.
AC A0A3B4UJ71;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=SH2 domain-containing protein 3C-like {ECO:0000313|Ensembl:ENSSDUP00000018624.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000018624.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000018624.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4UJ71; -.
DR STRING; 41447.ENSSDUP00000018624; -.
DR Ensembl; ENSSDUT00000018959.1; ENSSDUP00000018624.1; ENSSDUG00000013546.1.
DR GeneTree; ENSGT00940000154130; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 189..288
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 499..767
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 28..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 85778 MW; 3FCA14229D5EC2F0 CRC64;
TSTSAQKTGS RFTRWGFKWF GSLTNLSTRR SPEKANIKEA PEHDGSLIGA KPEAVGNQSV
DDMESCLHSP SYARSTDMYT HVGTVPRSER QKKSCKGVGR SAPEQEEEEA ERETGGEETW
SQCVFVLNSE TTCQRHESPV SLAAGPRNFR GTVSFSKEKF WLEPPSEQQR KQLEEELKLS
GTNLKSHAWY HGQIPWEVSE SLVLNHGDFL IRDSQSSPGD FVLTAHWEQE TLHFLIRKTA
VQSGETYTRV QYSLEGEAFD SIPALVHFYV GGRAALSRWS GAQIHRPVNR TLPLTYLETA
FCTAVGAPPC PRGLRSGEER VCPRRWDLTS LPLSEENKLS VARIHKYPSL PSLPPSPAPQ
SRSPCSSRAV SVAPSPSLPR CSDTAQPPTS PNSTLHRERD DRPQPHPNQD SPFSDTDGSC
YTELYPGPQS YVERLRVEEG SAGLDPLRVE DGNANFSPVV ETVSSFKPSG YQSPLMPKEN
KPLEVGVLRR VKELLAEIDP RTAAKHITKA DCKMARILEV TPEMQRMMGV SSGMELLTLP
HGQQLRLDLL ERFQTMAIML AVDVLGCTGT NEERAGLLHK IIQIAAELKS TMGNMFGFAA
VMRALELPQV SRLEQTWMAL RQRHTEGAIL YEKSLRPFMK SLNDGRESCP LSNTTFPHVL
PLLSLLEKSV AVGEGTEPWE TVEVGVDVVM FHLGAARTIA QLGGIYRSNA ESKLQGFQEQ
AEVLELFLTD FQMRLLWGSR GATENQALRY AKFDQVLTAL SNKLEPPVRS R
//
