ID A0A3B4UJK0_SERDU Unreviewed; 580 AA.
AC A0A3B4UJK0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=P2X purinoceptor {ECO:0000256|RuleBase:RU000681};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000018754.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000018754.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel.
CC {ECO:0000256|RuleBase:RU000681}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000681}.
CC -!- SIMILARITY: Belongs to the P2X receptor family.
CC {ECO:0000256|ARBA:ARBA00009848, ECO:0000256|RuleBase:RU000681}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000681}.
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DR AlphaFoldDB; A0A3B4UJK0; -.
DR STRING; 41447.ENSSDUP00000018754; -.
DR Ensembl; ENSSDUT00000019092.1; ENSSDUP00000018754.1; ENSSDUG00000013676.1.
DR GeneTree; ENSGT01020000230351; -.
DR OMA; WCKCGCC; -.
DR OrthoDB; 5312692at2759; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004931; F:extracellularly ATP-gated monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0001614; F:purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0033198; P:response to ATP; IEA:InterPro.
DR Gene3D; 1.10.287.940; atp-gated p2x4 ion channel; 1.
DR Gene3D; 2.60.490.10; atp-gated p2x4 ion channel domain; 1.
DR InterPro; IPR046815; P2RX7_C.
DR InterPro; IPR003050; P2X7_purinoceptor.
DR InterPro; IPR027309; P2X_extracellular_dom_sf.
DR InterPro; IPR001429; P2X_purnocptor.
DR NCBIfam; TIGR00863; P2X; 1.
DR PANTHER; PTHR10125; P2X PURINOCEPTOR; 1.
DR PANTHER; PTHR10125:SF13; P2X PURINOCEPTOR 7; 1.
DR Pfam; PF20478; P2RX7_C; 1.
DR Pfam; PF00864; P2X_receptor; 1.
DR PRINTS; PR01314; P2X7RECEPTOR.
DR PRINTS; PR01307; P2XRECEPTOR.
DR PROSITE; PS01212; P2X_RECEPTOR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU000681};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000681};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000681};
KW Receptor {ECO:0000256|RuleBase:RU000681};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000681};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000681};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000681}.
FT TRANSMEM 30..46
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000681"
FT DOMAIN 380..565
FT /note="P2X purinoreceptor 7 intracellular"
FT /evidence="ECO:0000259|Pfam:PF20478"
FT REGION 432..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 65507 MW; 031C1D66D8737971 CRC64;
MPCCNLLSLC QYDTNKLVRI QSVRLGSLKW SLNAAILLFI CIMMLWNRKY QEFDLVVSSV
TTKVKGVAQT RLPGVGDVVW DVVDYSGPSQ DKNSFFVVTN VIVTKNQQQG KCPEAPRNGR
LCRTDKDCEK GAWDQQSHGI QTGSCVKFDV LKKTCEVSAW CPIESKTTPP RPALLGAAEN
FTVLIKNNIR FPAFNFFRRN ILPNMNDAYL RSCQRGNDSL CPIFRLGDVV REAGEKFSVM
AVEGGVIGIL IKWDCNLDRL MQRCLPRYSF RRLDEKESNR TLYPGLNFRY AKYNTVNGVE
ERTLYKAFGI RFDVMVFGQA GRFSFIQLII YIGSTLSYYA LTTVLLDWLI GTSCYSAEVG
QNYSEKKVEP VQDKQKCVLC VSYVDESNIR LVKRSLKKSL QDVKPMSVQP RKEDRGHLRA
ALCLLQPGVA ADQDAQPPLD HRPDPKPKPH RPAWCRCDCC TPSSLPQEEL CCRQSDGACI
TSSPLFEQLV LRRPLLEAVL LYRHPLSPPA DRGQTTALRH CAYTQYISWR FGDTSDGTHP
AIPRCCVQRV REEYSSPDGQ YSGFRPASMV SMEACANGEL
//
