ID A0A3B4UL60_SERDU Unreviewed; 704 AA.
AC A0A3B4UL60;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SRP receptor subunit alpha {ECO:0000313|Ensembl:ENSSDUP00000019097.1};
GN Name=SRPRA {ECO:0000313|Ensembl:ENSSDUP00000019097.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000019097.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000019097.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family.
CC {ECO:0000256|ARBA:ARBA00008531}.
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DR AlphaFoldDB; A0A3B4UL60; -.
DR STRING; 41447.ENSSDUP00000019097; -.
DR Ensembl; ENSSDUT00000019441.1; ENSSDUP00000019097.1; ENSSDUG00000013920.1.
DR GeneTree; ENSGT00550000074936; -.
DR OMA; HLGWIDK; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005785; C:signal recognition particle receptor complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005047; F:signal recognition particle binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd14826; SR_alpha_SRX; 1.
DR CDD; cd17876; SRalpha_C; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.140; Signal recognition particle SRP54, nucleotide-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007222; Sig_recog_particle_rcpt_asu_N.
DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR InterPro; IPR036225; SRP/SRP_N.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR InterPro; IPR042101; SRP54_N_sf.
DR PANTHER; PTHR43134; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43134:SF1; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF04086; SRP-alpha_N; 1.
DR Pfam; PF00448; SRP54; 1.
DR Pfam; PF02881; SRP54_N; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SMART; SM00963; SRP54_N; 1.
DR SUPFAM; SSF47364; Domain of the SRP/SRP receptor G-proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00300; SRP54; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}.
FT DOMAIN 676..689
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|PROSITE:PS00300"
FT REGION 182..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 77928 MW; EA66712C9786B1EB CRC64;
MVYNQTAHAR NLRRGGDGSK CHFLAVHLTC LKQFYTGGGF YHLLKYYLIR GGKMLDFFTI
FSKGGIVLWC FQGAGVTESF TGPVNALIRS VILQERSGNN SFTHEALSLK YKLDNEFELI
FVVGFQKILT LTYVDKFIDD VQLHFRDRYK NELEQKGALK LLNNNFEFED IFKMLLREAE
ESSKARSHAP MRSFKESEKS QKTVKSMIET KGGDKSKEQG GKKNKNTKKE APAAEPAKGD
QGKPTPSGQK MVENGNQGLT PEEVIEKNKE KLFRKRMVTT TEKPRKSPKP QKPREKQMRV
WDMGGSSTKD LDYSYNGDNC SPSNGGEQHL EAQNDPGMQV SSMEGDLLPV DYESSEEGEI
GEEDERVIVS ETSKTSSKKG GSFGGMFGML KGLVGSKSLT REDMESVLEK MRDHLITKNV
AADIASQLCD SVAKKLEGKV MGTFTTVAST VKQALQDSLV QILQPKRRVD ILRDVMEAQS
QRRPFVITFC GVNGVGKSTN LAKISFWLIE NGFTVLIAAC DTFRAGAVEQ LRTHQRRLNS
LHPPEQHGGR PVVQLYEKGY GKDAAGIAME AIAYARNQAF DVVLVDTAGR MQDNAPLMTA
LAKLIAVNMP DLVLFVGEAL VGNEAVDQLV KFNQALADHS MSDKPRLIDG IVLTKFDTID
DKVGAAISMT YITGQPIVFV GTGQTYNDLR SLNARAVVGA LMKA
//
