ID A0A3B4UPT4_SERDU Unreviewed; 1177 AA.
AC A0A3B4UPT4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Protocadherin 12 {ECO:0000313|Ensembl:ENSSDUP00000019750.1};
GN Name=PCDH12 {ECO:0000313|Ensembl:ENSSDUP00000019750.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000019750.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000019750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4UPT4; -.
DR STRING; 41447.ENSSDUP00000019750; -.
DR Ensembl; ENSSDUT00000020099.1; ENSSDUP00000019750.1; ENSSDUG00000014388.1.
DR GeneTree; ENSGT00940000160403; -.
DR OMA; ALFMSIC; -.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF42; PROTOCADHERIN-12; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1177
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017214050"
FT TRANSMEM 717..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..130
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 131..239
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 240..347
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 353..458
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 459..567
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 617..711
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 231..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1177 AA; 129100 MW; 46EC869BB30D697F CRC64;
MMLLALLLVL SLCSEARSSE PSSITIQYRV WEEQPAGTQV GRLVDDLRQR DEGGPLEDFQ
VVEHGKALPF SVSTRNGVVS TQGRLDREEL CRGSDLCEVA FSVLYRKSGA VNCLRVRVEV
MDLNDHSPSF PGPLQEVEIS ETASLRMRIP LDRAVDPDAG PNSLQTYSLS VNQHFALDVT
VGPDGTKQAE LVVIKELDRE LQTSFNLTLV AWDKGNPPRS GSTLVRVNIQ DSNDNSPTFE
DSSPTVELPE DTTRGTTIIN LKATDPDQGA NGEVEYSLSK HTRPEVQRLF YVDPQNGAVS
LRAPLDFEAH SSYEVIVQAR DRGPNAIPSH CKLHVKLKDV NDNAPRIHMT WTPPNSPVAT
VLEGAQEDTF LALVMVSDAD SGENGKVRAH IQHGSGPFRL KRIHGDNYMI VTNGSLDREK
VMQYNITVLA QDYGDPPLSC IKHLPVHVLD ENDNAPVFST SLYKTSFKEN NVAGYHALKV
EAHDVDLELS GRVSYFIPNS NDMETDTQSF SIHPTSGVIS IRRPLDYEES RTYSFIVEAV
DHGHPPLTST ATVQVDVEDV NDNYPVIKDP KPRKGVASLS VPVDAEKGEI VTELGNDMEE
ASTALPMNHP IRDGLVGFLA STIKAEDPDS GPNGELKYLI TDGNPDGLFW LDEATGQLFV
NTTNATELIG KTFKVDVAVS DMGTPSLVTE VTLEVSFINL KDHLKNSSPG NRGQLSFTMM
MAICLGATCL LLLLAIALVT TFCRPEKRDN RAYNCRQAES TYTRHPRRPQ KNIRKSDIQL
IPVIRGRKEE LSEDESESQP LAPPPIMSED VQTERQYTLT QSAMNTSFHS QGYPEGDPAQ
TVTHHCRTLR KPGNIELDGS LPLTPATSYR TLRKARNPSS SSSLSHSSTL KRQGHPEGEG
EEPACSGSQA TLRRPKTSEG RGGQDAEHRQ MLRNLVRLSM AAFGDSIELS SASPEVQQIS
QLLSLLRQGQ LQPRPNFRGN KYSHRRYGGQ DCSDWQSTKD SGHGESEAGD VDWEPGRDSP
IDPQLEEGLN NLLNNTDDVF SEVNDPAWMA RLSLPLTGDY HDNVFVPNGP PSPETELLPR
DALDSSSFST FGKTPEKDGP LGGTLLSEVS TLFEMLMTQK ADAHPGPRPD VLYRLSAAYR
RSLGLDGAAT PAAGNAARNS GNTEKRSGPA APSGRYQ
//
