ID A0A3B4UQ66_SERDU Unreviewed; 450 AA.
AC A0A3B4UQ66;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Desmin {ECO:0000256|ARBA:ARBA00040601};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000020517.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000020517.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000256|ARBA:ARBA00004216}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A3B4UQ66; -.
DR Ensembl; ENSSDUT00000020891.1; ENSSDUP00000020517.1; ENSSDUG00000014903.1.
DR GeneTree; ENSGT00940000155522; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652:SF2; DESMIN; 1.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}.
FT DOMAIN 107..416
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 16..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 300..394
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 436..450
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 51515 MW; E3BC2E4263EC2CC8 CRC64;
MSKSYSASAQ SASSYRRTFG SGVGSSPMSS LFSSGGGRSS SSSHMSSRVY EVKSSGIPSF
SGYRVSSGAG GAGFGSSTAM RTYSGEKLDF NLADAMNQDF LNTRTNEKAE LQHLNDRFAS
YIEKVRFLEQ QNAALTVEIE KLRGREGPGR VAELYEEEMR ELRRQIEALS NQRARVEVER
DNLGDDLQKL KLRLQEEIHQ KEEAENNLSA FRADVDNATL ARLDLERRIE SLQEEIAFLK
KIHEEEIREL QSQMQDTQVQ VQMDMSKPDL TAALRDIRMQ YEAIAAKNIA EAEDWYKSKV
SDLNQAVNKN NDALRQAKQE SMEYRHQIQS YTCEIDSLKG TNESLLRQMR DMEDRMSREA
SGYQDTITRL EEDIAKMKDD MARHLREYQD LLNVKMALDI EIATYRKLLE GEESRWLFEC
VLTETSPESQ HQPHTHMRTH THTHTHTLHV
//
