ID A0A3B4UQ80_SERDU Unreviewed; 1844 AA.
AC A0A3B4UQ80;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000020624.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000020624.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSSDUT00000021000.1; ENSSDUP00000020624.1; ENSSDUG00000009211.1.
DR GeneTree; ENSGT00940000154992; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF295; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 384..411
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 607..631
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 677..695
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 707..725
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 797..820
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 875..900
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1072..1090
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1111..1127
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1139..1158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1203..1223
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1311..1334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1390..1408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1420..1442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1454..1473
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1521..1543
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1611..1634
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 137..417
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 676..907
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 957..1066
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1070..1342
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1389..1644
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 436..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..999
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1844 AA; 210481 MW; F3C025D6E1FF70E1 CRC64;
MAGCVFPMGP ESFQRFTPDS LAAIEQRIAQ EEARRKKHYQ EDLGDVELPK PRPDLEAGKQ
LPRIFADIPS HLVGVPLEDI DPYYFKDQRT FIVLNKGKAI FRFSATSALY IFSPFHPVRR
IAIKILVHSY PSTAAPLFIM CTILTNCCFM AMSEPAYWAK YLEYTFTGIY TFESLIKILA
RGFCVGPFTF LRDPWNWLDF SVIVMAYVTE FVDLGNVSAL RTFRVLRALK TISVIPGLKT
IVGALIQSVK KLADVMILTV FCLSVFALIG LQLFMGNLRQ KCVQSPELKF KRNWNLKWNF
ILFFSLDNFY KVEGAKDALI CGNSSDAGKC PDGFDCLKAG RNPNYGYTSF DTFGWAFLSL
FRLMTQDYWE NLYHQTLRSA GKTYMVFFVV VIFLGSFYLV NLILAVVAMA YEEQNQATIA
EAWQKEREFQ QAMERLKKEQ QVNHESSAES SFDGHVGRGG EPIGGEAAAG GHDGRREGEG
RRIWTPVVLI LLLVIFPNIS HVLLLPSPQP LHPLLARSFS TRTRRSSQVS SIFNFRLRSR
GSEGEMADDE YSVPGDVVEG VGGRTYSGGT FSGILPHPWP KRRPSTYSTA SRVCPPAPFT
NPNPTHLLPL SLIICRVLYC PLVLLSSSVL GRAELEESNK KCHPCWYVFA HRYLVWECCP
WWLRVKQLVK IMVMDPFLDL AITVCIVLNT LFMAMEHYPM TDEFNGMLSI GNLVFSGIFT
AEMVLKIIAL DPYYYFQTGW NIFDSIIVCL SLMELGLSDV EGLSVLRSFR LLRVFKLARS
WPTLNTLIKI IGNSMGALGN LTLVLAIIVF IFAVVGMQLF GKNYQDCVCK ISKDCALPRW
HMKDFFHSFL IVFRVLCGEW IETMWDCMEV AGQPLCILVF MLVMVIGNLV LLNLFLALLL
SSFSSDNLSA PDDDGEMNNL HIAIHRITRG LAWCRRQVPD KQPLCGGRHV EKYVVPEEDS
YMTNPNLTIS VPIAPGESDV EFPEEEDEEE EEGEEEQNDI SLSEGSTVDL RKPGEEEDEY
SEMAEEAMDP DNCFPDMCVA RFHCCDIDTT AGLGQIWWRM RKTCYQIVEH SWFESFIIFM
ILLSSGALAF EDIYIEQRKV VKVILEYADK IFTYIFILEM MLKWLAYGFK KYFTNYWCWL
DFLIVDVMLG HLVANTLGYS DFAAIKSLRT LRALRPLRAL SRFEGMRVVV NALIGAIPSI
MNVLLVCLIF WLIFSIMGVN LFAGKFGRCI NRTGHIYEAS FINNKSECEA LNDTSLFYWT
KVKVNFDNVG AGYLALLQVA TFKGWMEIMY AAVDSRAVEE QPIKEINLYM YLYFVIFIIF
GSFFTLNLFI GVIIDNFNQQ KRKINVFLCV EQKKYYNAMK KLGSKKPQKP IPRPLNTVQG
FFFDLVGKQA FDIIIMVLIL FNMITMMVET DEQSPQMEYI LNNVNLAFII VFTAECLIKI
VALRCYFFTV GWNIFDFVVV ILSIVGIVLA DIIEKYFVSP TLFRVIRLAR IGRILRLIRG
AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IYAIFGMANF AYVKRQSGID DMFNFETFGN
SMICLFQITT SAGWDSLLSP ILNNSPEECN PNIPHTGTTV KGNCGNPSVG ITFFVTYIII
SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFEMFYEVW EKFDPEATQF IEYAKLSDFA
DSLSEPLRIA KPNKIKLISM DLPMVSGDKI HCLDILFAFT KRVLGESGEM DALKQQMEEK
FMMANPSKIS YEPITTTLRR KQEEVSATVI QRCYRRHLVR RQMKAASYLY HEVSKCVCTA
FVQSASISIF RTTSLSPSLL SWKKKKKKKK FYWHRLDSIS TRFY
//
