ID A0A3B4URN9_SERDU Unreviewed; 833 AA.
AC A0A3B4URN9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Protein tyrosine phosphatase receptor type N {ECO:0000313|Ensembl:ENSSDUP00000020440.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000020440.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000020440.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 8 subfamily. {ECO:0000256|ARBA:ARBA00025723}.
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DR AlphaFoldDB; A0A3B4URN9; -.
DR STRING; 41447.ENSSDUP00000020440; -.
DR Ensembl; ENSSDUT00000020809.1; ENSSDUP00000020440.1; ENSSDUG00000014837.1.
DR GeneTree; ENSGT00940000154095; -.
DR OMA; AQTGFQI; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 563..823
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 742..814
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 67..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..282
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 91870 MW; 9D4657C6E63F5C20 CRC64;
CTRDQFCSDD GLFGQCLSSK QDQVQYQVSV PVLKRMQEVL KQLMLQGLSW QDDITQYILS
KELKRVPHTT HPSKSKQHVP HHHSSKSGST PSAGNYVDYM IVEPPQSQLR CVSAAQVYAR
PSSRSQASQR ERERDRQLLQ EALSLYLASA QPSYRHRGAA SMAPAGLPYY DDLELDIPMD
YVEGYTLEER LGTAGRQQML QNKKVPQDYS TLSGNNDGLL QRMSGVLQRY GVDPRELSQE
QLYKLALILQ LLQMQLLKTD SVSNKPQKPV PVPGPPDAPL APSSASIPAT PAAKSASPPP
SATQPPQAAP AEAGQGLKEQ GPPLVEGMGA KEEYGYIVTN QSPLGLYDGV KLLELLADKI
HLTTSSFINI SVVGPALTFR IRQNEHNMTA AEVAAKAVSE KNFLESQTGL KIVQTGVGER
TDARGLPQVT RVSQGSSGTV ITLVSMAVVG GVLVLAMAVA CLRHYAQQVA NGKLGLGPEG
GAETHFDYQD CVATGAGGRR GTDTSRVSSV SSQFSDGPQH SPSSTHSSTP SWSEEPAQSN
MDISTGHMIL AYMEDHLRNK DRLQKEWEAL CSYQAEPSSV AAAQVPSNMD KNRNAESLPY
DHTRVKLKTE LNPNKQDYIN ASIIFDHDPR QPAYIATQGP LSHTVADFWQ MVWENGCTVI
VMMSALVEDG EKQCERYWPD EGSSLYHIYE VNLVSEHIWC KDFLVRSFYL KNVQTQETRT
LTQFHLLSWP ADGIPTSTRP LLDFRRKVNK CYRGRSCPII VHCSDGTSRT GTYILIDMVL
NRMAKGVKEI DIAAALEHIR DQRPGLVRTK DQFEFALTAV AEEVNAILKA LPQ
//
