ID A0A3B4URY8_SERDU Unreviewed; 914 AA.
AC A0A3B4URY8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 5 {ECO:0000313|Ensembl:ENSSDUP00000021194.1};
GN Name=ITIH5 {ECO:0000313|Ensembl:ENSSDUP00000021194.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000021194.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000021194.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR AlphaFoldDB; A0A3B4URY8; -.
DR STRING; 41447.ENSSDUP00000021194; -.
DR Ensembl; ENSSDUT00000021584.1; ENSSDUP00000021194.1; ENSSDUG00000015411.1.
DR GeneTree; ENSGT00940000158317; -.
DR OMA; AKKFIYT; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF62; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..127
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 267..451
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 77..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 101253 MW; E8E7EE84B281A10E CRC64;
PRQVKTLLTK ETKPHIQELS IKTTIISRYA FTAVYCAMLN RHSAATEGVF QFQIPADAYV
SNFTMIIGGR VYQSEVRPKE KRVKQENGKP KNKESGDASP EPQVEVFRTA VNIPGRNRAV
FLLTYEELLQ RRLGRYEHVT SLRPLQLVSR LSLDVTIVDH SLITDLEVLP LRNGRSTGAT
NVPSAPKTPA KPEPPVTTVT KNEKNVCKIT FSPNIVQQAK ITTSGILGDF VIRYDVQRDM
GIGDIQVLNG HFVHYFAPKD LPVVPKNVVF VIDTSASMLG TKIRQTKDAL FTILRDLRPD
DHFNFISFSN KIKVWQPDRL VPVTPLNVRD AKKFIFTLMP TGGTNIDDAI QTGSTLLRRY
LSGPDASPNS VSLIIFLTDG RPTVGEIQST AILGNTRSAV EEKFCIFTIG IGNDVDYRLL
ERMALENCGM MRRIHEEADA SAMLKGFYDE IGTPLLSDIR INYTEDSVKY VTQHMFTNYF
NGSEIVIAGK LTNQSAESLH VQVTASNNDK SIILETDVPL RHRQMETANH VKAATTAMDF
VERVWGFLSV KEGLRSRLRS QTSKEREGHT NQATNLSLTY HFLTPLTNLV VEKPEVLADG
TMAPAPTINP AAGEAVSTAN ELPEEALNNC SPLSHLQKIN ILFLVGKVER RPAKKSITIS
KTSADGDPHF VVEFPLSKLT VCFNINGEPG HILRLVSDHK HSGVTVNGKL IGAPPPPGSH
KQQRTYFSTI TVVVDHPKRA YIEVTPKKVI LDGRDRIVLP CHSTAAVDSG ALSVSIVGRS
NVTVTVGGNI SFVILLHQYK NPAPYQRDHL GFYIGNSKGL SHNCHGLLGQ FLYEEVGLAE
LPAQGGTKPS PVLKVKDRSV PVVQKSRRIY SGTQSVDCWF ARNNAAKLID GQYEDYLMSH
MFDTGDWPHG SNRV
//
