ID A0A3B4UVG6_SERDU Unreviewed; 836 AA.
AC A0A3B4UVG6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN14 {ECO:0000313|Ensembl:ENSSDUP00000022566.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000022566.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000022566.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR AlphaFoldDB; A0A3B4UVG6; -.
DR Ensembl; ENSSDUT00000022980.1; ENSSDUP00000022566.1; ENSSDUG00000016356.1.
DR GeneTree; ENSGT00940000156874; -.
DR OMA; VGEFRIT; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 2.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}.
FT DOMAIN 21..299
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 558..829
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 739..820
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT ACT_SITE 770
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 836 AA; 96604 MW; 9E09BB1D0ED78949 CRC64;
MPFRLKLRRT RRYNVLSKNY FVTRIRLLDS NVIECTLSVE STGQECLEAV AQRLELRETH
FFGLWFQGKT QAPAQRWVEL EKPLKKQLDK FGNEPLLFFG VMFYVPNVSR LEQEATRYQY
YLQVKKEVLD GRLHCTVEQG IRLAGLAVQA DFGDFTQFMS QDFLREYVLF PEKDSETMTF
LYLYLCVLSS RMQAAEAELL YIKEVEKLDG FGQESFAAKD NYTNDIFIGV SFIGVFVKHR
NGRSIMWKDI GTIAHNKSAI TVEITSRDDT IIFHMEDMEM AKYIARLFTA RHKFYKQNKI
CAEPTHSPAP IRRRPTWTHR LSLVPSQAFA LFDMLFVYYP SYSFILPHYF CSLDSIFHDD
PYYKSETSLD RCPVDFPFRN GTVPNGSMYS SPSLSSLNHS QTFVPPSPIS SNLSIPGSEL
MRPDYIPSHR HSAIIAPSYR PTPEYDAVMR QKRHMLPAHH DLHSQSLRSL NISNACAYRQ
PEALVYSQPE MRERGPYHVA YQHQKTLSNT LERQKMSVDS MKRPLMMAAL NGLYVARMPV
PKGPSEEGAK LKLEEERVFT EYEQVPKKRA NCVLTTATLP ENTERNRFRD VVPYEENRVE
LVPNKENNTG YINASHIKVM IRGEEWHYIA TQGPLANTCA DFWQMVWEQG VNVIAMVTAE
EEGGRSKSHR YWPKLGSKHN SATHGKFKVT TKFRTDSGCY ATTGLKVKHL LSGQERTVWH
LQYTDWPEQG CPEYVMGFLS YLEEIQSVRR HTNSMLDTSK SLNPPVVVHC SAGVGRTGVV
ILTELMISCL EHNEPMEVPT MLSELRQQRM LMVQTISQYK FVYQVLIQFL KNSRLI
//