ID A0A3B4UY65_SERDU Unreviewed; 323 AA.
AC A0A3B4UY65;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588, ECO:0000256|RuleBase:RU365059};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000023483.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000023483.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181,
CC ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR AlphaFoldDB; A0A3B4UY65; -.
DR STRING; 41447.ENSSDUP00000023483; -.
DR Ensembl; ENSSDUT00000023918.1; ENSSDUP00000023483.1; ENSSDUG00000017084.1.
DR GeneTree; ENSGT00950000183172; -.
DR OMA; ATHNYFL; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17871; GPN2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030231; Gpn2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059}.
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 36252 MW; 305D672C6FEDCEF4 CRC64;
MPPSLLGTET MSSQTGATPP LRFGQVVIGP PGSGKTTYCQ GMQEFLTHLG RKVVVVNMDP
ANEGLPYSCD INISELVTLD DVMEGLKLGP NGGLLYCMEY VEANLDWLQN KLKQHSDCYF
LFDCPGQVEL YTHQNSVKNI FSQLAKWNFR LTAVHLVDSH YCADPAKFIS VLCTSLSTML
HVELPHVNIL SKMDLIEQYG KLAFNLDFYT EVMDLTYLLD HLAADPFFKK FHHLNEKLAE
VIQDYGLVSF VPLNVQDKES MIQVLRAVDK ANGYCFGDLE ERNLQAMMSA AVGADFQFDS
TLGVQERYVE TSGKTVEEEM MDL
//
