ID A0A3B4UZS2_SERDU Unreviewed; 1302 AA.
AC A0A3B4UZS2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=RAS protein activator like 2 {ECO:0000313|Ensembl:ENSSDUP00000023792.1};
GN Name=RASAL2 {ECO:0000313|Ensembl:ENSSDUP00000023792.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000023792.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000023792.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 41447.ENSSDUP00000023792; -.
DR Ensembl; ENSSDUT00000024236.1; ENSSDUP00000023792.1; ENSSDUG00000017264.1.
DR GeneTree; ENSGT00940000157702; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 32..281
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 272..390
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 450..643
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 85..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1155..1214
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 95..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..1004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1302 AA; 145271 MW; DB809F65C8E5BA29 CRC64;
METDSVAGDV ESLHGGLSLL DPLVDRILVD TVSQQQGWLR VYDVKGPPAH RFSCGQSPYT
DSGAWERKYC ILTDTQLILL HKDDEAAGDA QESPTDSAKG RSLRRTVSVP SEGQFPEFQA
EGATMLEVSS ERSPRRRSIS GLGSSEKSVA IDNPNSSPFK VPGFFSKRLK GSIKRTKSQT
KLDRNTSFRL PSLRPAEPDR SRGLPKLKES SSHESLLSPG SAVEALDLSM EEDVFIKPLH
SSILGQEFCF EVTYSGGSKC FSCTSASERD KWMENLRRTI QPNKDNCRRA ENLLRLWIIE
AKDLPPKKKY FCELCLDDVL YARTTSKTRH DSLFWGEYFD FSSLPAVHSV TVHIYRDVDK
KKKKDKNNYV GLVNIPVSGV TGRQFVEKWY PVSTPTTSKA KGGGPSIRIK SRFQTISILP
MEQYKEFAEF ITNNYTMLCS VLEPVISVKN KEEMACALVH ILQSTGRAKD FLTDLVMSEV
DRCADHDVLI FRENTLATKA IEEYLKLVGQ KYLHDALGEF IKALYESDEN CEVDPSRCPS
GDLSEHQSNL KMCCELAFCK IINSYCVFPR ELKEVFASWK QQCVVRGHQQ DISKRLISAS
LFLRFLCPAI MSPSLFNLMQ EYPDDRTSRT LTLIAKVIQN LANFTKFGNK EEYMAFMNDF
LEHEWAGMMR FLSEISNQET LSNTPGFEGY IDLGRELSVL HALLWEVVSQ LDKGENSFLQ
ATVAKLGPLP RILGDISRSL AAPTPVQQQL RRFQDHSSAH NISGSLSSGL QRIFEDPVDS
HCEVRSLQSP GGDRMEGYVR GQRPLLAHQH PSVHSSFSDQ EERDNLLPNG RSISLVDLQD
AQSLHGPAAP PPHHEAPPRL SRVGSQASIG QGPPPLNYPH SNPLTPQPHQ MKAPPRDGQP
QSAPQVRRPL HPSLSQQRSL QPLSFQNPVY HLSNPTHSLS TRSAHSLRQD SSSENLSTES
SHNSHSNSDD YGSQVGVKGR VASNSSLDEL GSRRSTQSEE CSTPRRNVPP DLPPGVATAV
AIPRQSTTAG TAHIVKVEQQ SRGGAGARAP RSLPHSASLR SSSSANTEPT PTSGHTNRQQ
STCSVENMAP PPRSATKQPQ QVASPVEAVA VALSPVERTA AWVLNNGQYE EKEEEGGGDR
SREEGRNTEK YELEISRLKE RLRVSGRRLE EYERRLLAQE QQMQKLLLEY KNRLEDSEER
LRRQQEEKDS QMKSIICRLM AVEEELKRDH AEMQAVIEAK QKIIDAQEKR IGSLDAANSR
LMAALTQVKE RYSAPNLCNG LSPSNPTKLS ITENGEFKNS SC
//