ID   A0A3B4V7Q9_SERDU        Unreviewed;       765 AA.
AC   A0A3B4V7Q9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 {ECO:0000256|ARBA:ARBA00021134};
DE            EC=2.1.1.296 {ECO:0000256|ARBA:ARBA00012770};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000026622.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000026622.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-
CC         ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine =
CC         a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-
CC         ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-
CC         adenosyl-L-homocysteine; Xref=Rhea:RHEA:67024, Rhea:RHEA-COMP:17169,
CC         Rhea:RHEA-COMP:17170, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:167612, ChEBI:CHEBI:167614;
CC         EC=2.1.1.296; Evidence={ECO:0000256|ARBA:ARBA00024560};
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DR   AlphaFoldDB; A0A3B4V7Q9; -.
DR   STRING; 41447.ENSSDUP00000026622; -.
DR   Ensembl; ENSSDUT00000027098.1; ENSSDUP00000026622.1; ENSSDUG00000019312.1.
DR   GeneTree; ENSGT00940000161773; -.
DR   OMA; LHYCEAT; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; IEA:UniProt.
DR   Gene3D; 3.40.50.12760; -; 2.
DR   InterPro; IPR025807; Adrift-typ_MeTrfase.
DR   InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR16121:SF2; CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2; 1.
DR   PANTHER; PTHR16121; UNCHARACTERIZED; 1.
DR   Pfam; PF01728; FtsJ; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51614; SAM_MT_ADRIFT; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00946};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00946};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00946}.
FT   DOMAIN          114..329
FT                   /note="Adrift-type SAM-dependent 2'-O-MTase"
FT                   /evidence="ECO:0000259|PROSITE:PS51614"
FT   ACT_SITE        282
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
FT   BINDING         153
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
FT   BINDING         174
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
FT   BINDING         242
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00946"
SQ   SEQUENCE   765 AA;  85076 MW;  3280D11B4467D5B1 CRC64;
     MSSGNGTRRK VGKLQHFNNM VAPDPETLTE VQGLFSKVRI YVKPSNGEWC IPDPNIALKH
     QSEEHCRLQA LKVSLNAVKN QLSDKNVQVW HQHTNSTNRA GKVIAAVRSA ANPEICTQAW
     CKFYEILGTF DLLPDEALQS GELNTVHLCE APGAFITALN HYIKTSDCTR YCDWSWAANT
     LNPYHEANGG STTIADDRLI ANTLPWWFFG SDNTGNIMIQ KHLLELQVFV SNMRRVDMVT
     ADGSFDCQEN PDEQEALVAS LHYCEVTAAL LLLSPGGSFV LKMFTLYEHS SVCLLFLLNC
     CFHSVNVFKP ATSKAGNSEV YVVCLNYDGK EAVRPLLSKL IRNYGPHLAD REALFPNALI
     PESFLKQHEE VCSYFHTQQV ETITENLRLF EGMSTEQRQR LDHVRDCMAH EYLQRFQVSF
     LPRSRWISRN TVSPACCSVS AGRPLGQKKQ TGSFNERREL QTLTWRERIE RGYHANWIQR
     HCTEAEGTGC VLEGPLSECR VDSWYVIVGA ALPALRNSPF CEGGLLNHLN EALMETVVDW
     SCVTPCDSCH LVCTASILSS IAGICVDGDS DGNKKKSQCL VFGSRSVWGA CGSQIGDLVL
     TFSVEPSFPQ RGCIALHDGE PLYQQQLLGC VVFSLQTLNS GDALLLPVFS ALTRVTAAVV
     LCLHVCFRSV TFRCPPPSGV VGTVLVCVGF CPEAAARILP VLTEVHNCMS QLLRGEEGKS
     QSPGWDRQVL QFIPMEELLS GGLTEFLWTM NSEIIQQKLH LLMQS
//