ID   A0A3B4V9V7_SERDU        Unreviewed;       694 AA.
AC   A0A3B4V9V7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Regulator of G-protein signaling 12-like {ECO:0000313|Ensembl:ENSSDUP00000027598.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000027598.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000027598.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4V9V7; -.
DR   STRING; 41447.ENSSDUP00000027598; -.
DR   Ensembl; ENSSDUT00000028082.1; ENSSDUP00000027598.1; ENSSDUG00000019947.1.
DR   GeneTree; ENSGT00940000164407; -.
DR   OMA; RVERRCC; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd08706; RGS_R12-like; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003109; GoLoco_motif.
DR   InterPro; IPR003116; RBD_dom.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR046995; RGS10/12/14-like.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR   PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR   Pfam; PF02188; GoLoco; 1.
DR   Pfam; PF02196; RBD; 1.
DR   Pfam; PF00615; RGS; 1.
DR   Pfam; PF16613; RGS12_us1; 1.
DR   Pfam; PF16612; RGS12_usC; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00390; GoLoco; 1.
DR   SMART; SM00455; RBD; 2.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 2.
DR   PROSITE; PS50877; GOLOCO; 1.
DR   PROSITE; PS50898; RBD; 2.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          84..201
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          323..393
FT                   /note="RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50898"
FT   DOMAIN          395..462
FT                   /note="RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50898"
FT   REGION          211..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          558..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..260
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..611
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        668..682
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  75721 MW;  D8058D61FA5FA5E0 CRC64;
     MPGETLLSAQ SSVSCLSTGG HESSLSLMSL FVLFQSVASS DGDYSGLPLQ GCCSHSSLNS
     NGSLPGAGSH RGVPEQRVAS WAACFERLLQ DPEGVRYFSE FLKKEFSEEN ILFWQACEYF
     SHVPATDKKQ LSQRAGEIYN SFLSSKATMP VNIDSQAQLA DDVLTSPRPD MFKTQQLQIF
     NLMKFDSYSR FLKSSLYQEC MRAEVDGQPL PDPYQIPCSP APSKHSASSD RSTLSTPKKE
     ARKQRSGRSP NEDSRDESAD KKRGIFFSWS RNRSFGKGPK KKEIGDINLA DYWGSNGRRE
     SQGSLSSGTS LEMATSFWER SPKHCNVILP NGSCSSITLR PGASIRDVLQ DLCLNISVNI
     AAVDLFLVGG EKPLVLDQDC MTLSSRDLRM EKRTLFRLDL VPINRSVGLK AKPTKPVTEV
     LRPVVAKYGL HLSDLVSGET EPLDLGAPIS SLDGLRVVLD RVDPASGKGE TIYTSALLLL
     HLQGDERSTP KDFSVRSSGP DSALPGEKRK QKKINIDEAE EFFELLSRAQ STRANDQRGL
     LSKEDLVLPD FLRLTPPTSS CSVSSDLACS TPDSLKQSRE NGVSSRGLLT SSLRSESLDS
     SLSSSANGHS GNRRCLLPPP RHPTFGTHLS PISRPSDTRP TLRTVEEGAH SDLTLVGEGD
     INSPNSTLLP PSSPPPLPPL PPPLRLRMPS LVLL
//