ID A0A3B4VA99_SERDU Unreviewed; 1043 AA.
AC A0A3B4VA99;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSSDUP00000026870.1};
GN Name=MCF2 {ECO:0000313|Ensembl:ENSSDUP00000026870.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000026870.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000026870.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4VA99; -.
DR STRING; 41447.ENSSDUP00000026870; -.
DR Ensembl; ENSSDUT00000027347.1; ENSSDUP00000026870.1; ENSSDUG00000019428.1.
DR GeneTree; ENSGT00940000156974; -.
DR OMA; HNRRWPG; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..160
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 568..747
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 765..881
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 959..1020
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 888..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 118450 MW; 7E5642F14B8E709A CRC64;
VTVPVSMKEV GGYIEKQVAY LSGRGEDSSV IITLPECSAF SDIPEEALAK VFTYLTLIPT
RQPGVKFIII LDRRLDTWAS IKTALARIAA SFPGNLHLVL VLRPTSFFHR TVTDIGFRFS
QEDFMLKMPV VMLSSVTDLL RYISENQLTS EFGGTLDYCH SDWIVLRTAI ESFAVTVKDI
AHMLQGFGTD LAETELPDKG KAIEYLLECQ TDKYRKLKDA IRSVSKEGRH LLSSLETSGK
EDDSQWDVKL DWETVQLLAQ LRDMESAFDG FFEKHHLKLH QYMQLLRYEQ SFQEMELCLE
HLMAQERALS ISVDTLAQTE QALKRLDSLE SNAQEVVARA QIIILHGHQL SASHHYAIAL
IMQRCNELRH YCDTLNAALK TKHSRLLHTH QLLLCLGQAQ TWCDDGAYML ANQLVERFQS
KEGAQAALRD IEKFLEGAPS VLSSGPEILA IEYEAVITPQ LQAHIGKTFE KHAAVQQMIQ
NRQTCLKKLA DKHVRPIQLV APRPENPPRS KSPLFSPKHL KFTFDISLPG KRASRKSPNP
RKIEVIHDYQ ESRSCVSYGL EGEDSPDLLK HVMRELVETE RIYVEELLSV LLGYRAEMDN
PALWGLLPPI LRSKRDILFG NMPEIYNFHS VFLQDLEGCL EAPEGVGACF LERKESFQIY
ECYCQNKPRS EALLRQFSDC AFFLECQKKL EHKLGLESYL LKPVQRLTKY QLLLKELLKY
STDCEGTSEL QGALTAMLDL LKSVNDSMHQ IAITGYEGDI CELGRVLMQG SFSVWISHKK
GPTRMKELAR FKPMQRHLFL YERALLFCKR REEHGDGSDK TPSYSFKHCL KMTAVGITEN
VKGDVKKFEI WYSGREEVYV VQAPTLEVKM AWLNELRRIL TNQQKLLRSK QQRASVSSED
TESGRSSPDP QPHSPKHQHN RRWPGAHHSV DICEGLEEWS GGRDAFHPSD TEEEVLVQLA
PGRYRALADC LQNGPDSITI KCGDVIQLQC EDNKGRRLVK NLSRRQEGFI AAASLQLIIG
DSSRGHSSRL GPGNLKARKL SSP
//
