ID   A0A3B4VFS5_SERDU        Unreviewed;       691 AA.
AC   A0A3B4VFS5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Disks large homolog 2 {ECO:0000313|Ensembl:ENSSDUP00000029751.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000029751.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000029751.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4VFS5; -.
DR   STRING; 41447.ENSSDUP00000029751; -.
DR   Ensembl; ENSSDUT00000030263.1; ENSSDUP00000029751.1; ENSSDUG00000021455.1.
DR   GeneTree; ENSGT00940000155156; -.
DR   OMA; XYARFEA; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12032; SH3_DLG2; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR035759; DLG2_SH3.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 2.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          17..104
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          112..199
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          277..358
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          392..462
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          501..676
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
SQ   SEQUENCE   691 AA;  76644 MW;  1C491A9201B9FCF3 CRC64;
     FLFLQVNGTE IEYEFEEITL ERGNSGLGFS IAGGTDNPHI GEDPGIFITK IIPGGAAAED
     GRLRVNDCIL RVNDADVSEV SHSKAVEALK VAGSIVRLYV RRRRPMLETI IEIKLIKGPK
     GLGFSIAGGV GNQHIPGDNS IYVTKIIDGG AAQKDSRLQV GDRLLMVNNY SLEEVSHEEA
     VAILKNTSDV VYLKVGKPTN VYLSDPYGPP DITHSFSPAM ENHISSPINS GTLEYKSGLP
     SISPGSYSPL PKHLLGEEDI NSTQLPTVTL RCGEPRKVVL HKGSTGLGFN IVGGEDGEGI
     FVSFILAGGP ADLSGELRRG DQILSVNGID LRGATHEQAA AALKGAGQVV TIIAQYRPEE
     YGRFEAKIHD LREQMMNHSM SSGSGSLRTN QKRSLYVRAL FDYERSKDSG LPSQGLSFRY
     GDILHVINAS DDEWWQARRV TPHGDSEEMG VIPSKRRVER KERARLKTVK FNAKPGSFDS
     KRDILGIGDD GYGTKTFITY ARPIIILGPM KDRINDDLIS EFPDKFGSCV PHTTRPKRDY
     EVDGRDYHFV MSREQMEKDI QEHKFIEAGQ YNDNLYGTSV QSVKYVAERG KHCILDVSGN
     AIKRLQVAQL YPIAIFIKPK SIDSLMDMNK RLTEEQAKKI FDRAMKLEQE FGEFFTALVQ
     GDNLEDIYNH CKQVIEEHSG PYIWIPSKEK L
//