ID   A0A3B4VG28_SERDU        Unreviewed;       977 AA.
AC   A0A3B4VG28;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|Ensembl:ENSSDUP00000029584.1};
GN   Name=RAPGEF4 {ECO:0000313|Ensembl:ENSSDUP00000029584.1};
OS   Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000029584.1, ECO:0000313|Proteomes:UP000261420};
RN   [1] {ECO:0000313|Ensembl:ENSSDUP00000029584.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC       {ECO:0000256|ARBA:ARBA00010829}.
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DR   AlphaFoldDB; A0A3B4VG28; -.
DR   Ensembl; ENSSDUT00000030086.1; ENSSDUP00000029584.1; ENSSDUG00000021283.1.
DR   GeneTree; ENSGT00940000156075; -.
DR   OMA; LYCYVLE; -.
DR   Proteomes; UP000261420; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 2.
DR   CDD; cd04437; DEP_Epac; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.8.1240; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR   Pfam; PF00027; cNMP_binding; 2.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   PRINTS; PR00103; CAMPKINASE.
DR   SMART; SM00100; cNMP; 2.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          23..99
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          183..258
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          323..424
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          463..600
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          634..670
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          738..975
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   977 AA;  111730 MW;  7EA36032C246B7A1 CRC64;
     MNKDVSRNQL VFYNMFFQTV FSVYRQGDIG TNWYAVLSGS LDVKVSETSS YQDAVTICTL
     GTGTAFGESI LDNTPRHATI VTREISELLR IEQREFRSLW EKYHQFMAGL LAPPYGVMES
     GCSADKMPDK ENISNNSIVS VSKHQNKKSF IESPAKPHPK CISQVPSEKI LRAGKILRNA
     ILSRAPHMIR DRKYHLKTYR QCCVGTELVD WQMQQSSCVH TRIQAVGMWQ VLLEEGVLNH
     VDQELSFQDK YLFYRFLDDE QEDAPLPSEE ERQESQEELQ DTLLLLSQIG PDAHMRMILR
     KHPSERTADD LEIIYEELLH IKALSHLSTT VKRELAGVLI FESHAKAGTV LFNQGEEGTS
     WYIILKGSVN VVIYGKGVVC TLHEGDDFGK LALVNDAPRA ASIVLREDNC HFLRVDKEDF
     NRILRDVEAN TVRLKEHGQD VLVLEKSLSS SRTSVQGASS SHYKYKVMSG TPEKILEHLL
     EMMRLDSQFT ESDSALDDFV LMHCVFIPNS QLCPVLMAHY HAEALQGSEQ EKLDYTLNNK
     RRVIRLVMQW AAVHADHQQE EDNLVAFLEE FLMAVSNDAK AIAALRDQVT ELDRIVKRNA
     EDARLSQKKH KILLRQFSTG DEKLQKRQPI KSNDEILLKV YCCDHTYTTI RAPVATSVRE
     VIGAVADKLG SAEDLLLVNL SSAGEKVIFK PNDVSVFSTL SINGRLFACR RDQLDSLTPL
     PEQEGPSTGS LASFELMSSK DVAYHMTSYD WELFHCVHEL ELIYHTFGRQ NVKKTTVNLD
     LFLRRFNEIQ FWVISEMCMC SQLSKRVQLL KKFIKIAAHC KEYRNLNAFF AVIMGLSNPA
     VSRLSQTWEK LPSKFKKFYS EFENLMDPSR NHRAYRLTVA KLEPPIIPFM PLLIKDMTFT
     HDGNKTFIDN LVNFEKMRMI ANTVKIVRYC RSQPFSPDSP LASKNHPEVQ TYVRQLKVID
     NQRTLTQLSH GLEPRRS
//