ID A0A3B4VG28_SERDU Unreviewed; 977 AA.
AC A0A3B4VG28;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|Ensembl:ENSSDUP00000029584.1};
GN Name=RAPGEF4 {ECO:0000313|Ensembl:ENSSDUP00000029584.1};
OS Seriola dumerili (Greater amberjack) (Caranx dumerili).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=41447 {ECO:0000313|Ensembl:ENSSDUP00000029584.1, ECO:0000313|Proteomes:UP000261420};
RN [1] {ECO:0000313|Ensembl:ENSSDUP00000029584.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR AlphaFoldDB; A0A3B4VG28; -.
DR Ensembl; ENSSDUT00000030086.1; ENSSDUP00000029584.1; ENSSDUG00000021283.1.
DR GeneTree; ENSGT00940000156075; -.
DR OMA; LYCYVLE; -.
DR Proteomes; UP000261420; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 23..99
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 183..258
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 323..424
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 463..600
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 634..670
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 738..975
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 977 AA; 111730 MW; 7EA36032C246B7A1 CRC64;
MNKDVSRNQL VFYNMFFQTV FSVYRQGDIG TNWYAVLSGS LDVKVSETSS YQDAVTICTL
GTGTAFGESI LDNTPRHATI VTREISELLR IEQREFRSLW EKYHQFMAGL LAPPYGVMES
GCSADKMPDK ENISNNSIVS VSKHQNKKSF IESPAKPHPK CISQVPSEKI LRAGKILRNA
ILSRAPHMIR DRKYHLKTYR QCCVGTELVD WQMQQSSCVH TRIQAVGMWQ VLLEEGVLNH
VDQELSFQDK YLFYRFLDDE QEDAPLPSEE ERQESQEELQ DTLLLLSQIG PDAHMRMILR
KHPSERTADD LEIIYEELLH IKALSHLSTT VKRELAGVLI FESHAKAGTV LFNQGEEGTS
WYIILKGSVN VVIYGKGVVC TLHEGDDFGK LALVNDAPRA ASIVLREDNC HFLRVDKEDF
NRILRDVEAN TVRLKEHGQD VLVLEKSLSS SRTSVQGASS SHYKYKVMSG TPEKILEHLL
EMMRLDSQFT ESDSALDDFV LMHCVFIPNS QLCPVLMAHY HAEALQGSEQ EKLDYTLNNK
RRVIRLVMQW AAVHADHQQE EDNLVAFLEE FLMAVSNDAK AIAALRDQVT ELDRIVKRNA
EDARLSQKKH KILLRQFSTG DEKLQKRQPI KSNDEILLKV YCCDHTYTTI RAPVATSVRE
VIGAVADKLG SAEDLLLVNL SSAGEKVIFK PNDVSVFSTL SINGRLFACR RDQLDSLTPL
PEQEGPSTGS LASFELMSSK DVAYHMTSYD WELFHCVHEL ELIYHTFGRQ NVKKTTVNLD
LFLRRFNEIQ FWVISEMCMC SQLSKRVQLL KKFIKIAAHC KEYRNLNAFF AVIMGLSNPA
VSRLSQTWEK LPSKFKKFYS EFENLMDPSR NHRAYRLTVA KLEPPIIPFM PLLIKDMTFT
HDGNKTFIDN LVNFEKMRMI ANTVKIVRYC RSQPFSPDSP LASKNHPEVQ TYVRQLKVID
NQRTLTQLSH GLEPRRS
//